Causal effect of the age at first birth with depression: a mendelian randomization study

文献类型： 外文期刊

第一作者： Guo, Wanshu

作者： Guo, Wanshu;Guo, Yuanyuan;Zhang, Yu;Zhang, Aizhen;Meng, Fangrong;Chang, Minghang;Wang, Zhipeng;Guo, Wanshu;Guo, Yuanyuan;Zhang, Yu;Zhang, Aizhen;Meng, Fangrong;Chang, Minghang;Wang, Zhipeng;Huang, Xuankai;Wang, Zhipeng;Huang, Xuankai;Song, Shaokang

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关键词： Casual effect; Age at first birth; Depression; Mendelian randomization; Major depressive disorder; Postpartum depression

期刊名称：BMC MEDICAL GENOMICS （ 影响因子：2.1； 五年影响因子：2.5 ）

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年卷期： 2024 年 17 卷 1 期

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收录情况： SCI

摘要： Background This study aimed to explore the causal relationship between age at first birth (AFB) and depression. Methods Using the univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) methods to examine the potential correlation between age at first birth (AFB) and major depressive disorder and postpartum depression. A public database was used to obtain the genome-wide association studies (GWAS) summary data. We put inverse-variance-weighted (IVW) as the primary method in Mendelian randomization (MR) analysis and used sensitivity analysis to confirm the robustness of our result. Results We found a significant causal association between AFB and major depressive disorder by using the IVW algorithm (odd ratio [OR] 0.826; 95% confidence interval [CI] 0.793 - 0.861; P = 4.51 x 10(- 20)). MR-Egger, weighted median, simple mode and weighted mode method concluded the same result (P < 0.05). During the sensitivity analysis, the heterogeneity test (Q-value = 55.061, df = 48, P = 2.81 x 10(- 01), I-2 = 12.82%) and the leave-one-out plot analysis confirmed the stability of the results. The outcomes of the pleiotropy test (MR-Egger intercept = 8.932 x 10(- 3). SE = 6.909 x 10(- 3). P = 2.02 x 10(- 01)) and MR_PRESSO global test (P = 2.03 x 10(- 01)) indicated there is no pleiotropy. Conclusion There is solid evidence that a higher age at first birth is associated with a lower risk of major depressive disorder.

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