DExD/H-box helicases: multifunctional regulators in antiviral innate immunity

文献类型： 外文期刊

第一作者： Su, Chenhe

作者： Su, Chenhe;Zheng, Chunfu;Tang, Yan-Dong;Su, Chenhe;Zheng, Chunfu

作者机构：

关键词： DExD; H-box helicases; Antiviral innate immunity; TLR; cGAS-STING; NLR; RLR; ISGs

期刊名称：CELLULAR AND MOLECULAR LIFE SCIENCES （ 影响因子：9.207； 五年影响因子：10.002 ）

ISSN： 1420-682X

年卷期： 2022 年 79 卷 1 期

页码：

收录情况： SCI

摘要： DExD/H-box helicases play critical roles in multiple cellular processes, including transcription, cellular RNA metabolism, translation, and infections. Several seminal studies over the past decades have delineated the distinct functions of DExD/H-box helicases in regulating antiviral innate immune signaling pathways, including Toll-like receptors, retinoic acid-inducible gene I-like receptors, cyclic GMP-AMP synthase-the stimulator of interferon gene, and NOD-like receptors signaling pathways. Besides the prominent regulatory roles, there is increasing attention on their functions as nucleic acid sensors involved in antiviral innate immunity. Here we summarize the complex regulatory roles of DExD/H-box helicases in antiviral innate immunity. A better understanding of the underlying molecular mechanisms of DExD/H-box helicases' regulatory roles is vital for developing new therapeutics targeting DExD/H-box helicases and their mediated signaling transduction in viral infectious diseases.

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