Analytical Method Established via Derivatization-Integrated Gas Chromatography-Tandem Mass Spectrometry for the Determination of Enrofloxacin and Ofloxacin Residues: A Focus on Eggs and Dairy Products

文献类型： 外文期刊

第一作者： Xu, Junjie

作者： Xu, Junjie;Cai, Jingjing;Cheng, Sihui;Cao, Yang;Hong, Yiwei;Zhang, Tao;Zhang, Genxi;Guo, Xiaodong;Dai, Guojun;Xie, Kaizhou;Xu, Junjie;Ding, Hao;Cai, Jingjing;Gao, Pengfei;Cheng, Sihui;Cao, Yang;Hong, Yiwei;Zhang, Tao;Zhang, Genxi;Guo, Xiaodong;Dai, Guojun;Xie, Kaizhou;Ding, Hao;Gao, Pengfei;Xie, Xing;Pang, Maoda

作者机构：

关键词： Eggs; Dairy products; Enrofloxacin; Ofloxacin; Derivatization; GC-MS/MS

期刊名称：FOOD ANALYTICAL METHODS （ 影响因子：3.0； 五年影响因子：3.1 ）

ISSN： 1936-9751

年卷期： 2025 年 18 卷 7 期

页码：

收录情况： SCI

摘要： Preprocessing methods involving liquid-liquid extraction (LLE) and solid-phase extraction (SPE) were combined with gas chromatography-tandem mass spectrometry (GC-MS/MS) to perform qualitative and quantitative evaluations of enrofloxacin and ofloxacin in dairy products (raw milk and milk powder) and eggs (whole egg, albumen, and yolk). Trimethylsilyl diazomethane (TMSD) was applied as the precolumn derivatization reductant. The limits of detection (LODs) and limits of quantitation (LOQs) of enrofloxacin were 0.4 similar to 1.1 and 1.0 similar to 2.0 mu g/kg, respectively. The LODs and LOQs of ofloxacin were 0.1 similar to 0.2 and 0.2 similar to 0.4 mu g/kg, respectively. The recoveries of enrofloxacin and ofloxacin ranged from 79.78 to 92.33% and 78.26 to 90.79%, respectively. The RSDs were all less than 5.60%. The method was validated to satisfy the demand of the FAO & WHO (2014) standard. Moreover, successful utilization of this method is needed to satisfy the technical requirements of various laboratories.

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