Effect of theaflavin-3,3'-digallate on leptin-deficient induced nonalcoholic fatty liver disease might be related to lipid metabolism regulated by the Fads1/PPARd/Fabp4 axis and gut microbiota

文献类型： 外文期刊

第一作者： Zhou, Cheng

作者： Zhou, Cheng;Zhang, Luyun;Wu, Fan;Wang, Yan;Yu, Susu;Peng, Xinyue;Cheng, Wenli;Li, Min;Zhang, Wenjuan;Zhang, Wenji;Pan, Xiaoying;Huang, Zhenrui;Lin, Hui

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关键词： TF3; nonalcoholic fatty liver disease; RNA sequencing; 16S rRNA; lipid metabolism

期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：5.988； 五年影响因子：6.455 ）

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年卷期： 2022 年 13 卷

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收录情况： SCI

摘要： Nonalcoholic fatty liver disease (NAFLD), one of the risk factors for hepatitis, cirrhosis, and even hepatic carcinoma, has been a global public health problem. The polyphenol compound theaflavin-3,3'-digallate (TF3), mainly extracted from black tea, has been reported to produce an effect on hypoglycemic and antilipid deposition in vitro. In our study, we further investigated the function and novel mechanisms of TF3 in protecting NAFLD in vivo. By using leptin-deficient obese (ob/ob) mice with NAFLD symptoms, TF3 treatment prevented body weight and waistline gain, reduced lipid accumulation, and alleviated liver function injury, as well as decreased serum lipid levels and TG levels in livers in ob/ob mice, observing no side effects. Furthermore, the transcriptome sequencing of liver tissue showed that TF3 treatment corrected the expression profiles of livers in ob/ob mice compared with that of the model group. It is interesting to note that TF3 might regulate lipid metabolism via the Fads1/PPAR delta/Fabp4 axis. In addition, 16S rRNA sequencing demonstrated that TF3 increased the abundance of Prevotellaceae_UCG-001, norank_f_Ruminococcaceae, and GCA-900066575 and significantly decreased that of Parvibacter. Taken together, the effect of TF3 on NAFLD might be related to lipid metabolism regulated by the Fads1/PPAR delta/Fabp4 axis and gut microbiota. TF3 might be a promising candidate for NAFLD therapy.

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