Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination

文献类型： 外文期刊

第一作者： Hossain, Md Golzar

作者： Hossain, Md Golzar;Tang, Yan-dong;Zheng, Chunfu;Tang, Yan-dong;Akter, Sharmin;Zheng, Chunfu

作者机构：

关键词： furin cleavage site; host immune responses; pathogenesis; SARS-CoV-2; spike protein; vaccination

期刊名称：JOURNAL OF MEDICAL VIROLOGY （ 影响因子：20.693； 五年影响因子：12.203 ）

ISSN： 0146-6615

年卷期： 2022 年 94 卷 5 期

页码：

收录情况： SCI

摘要： The polybasic furin cleavage site insertion with four amino acid motifs (PRRA) in spike protein's S1/S2 junction site is important in determining viral infectivity, transmission, and host range. However, there is no review so far explaining the effect of the furin cleavage site of the spike protein on SARS-CoV-2 replication and pathogenesis in the host and immune responses and vaccination. Therefore, here we specifically focused on genomic evolution and properties of the cleavage site of spike protein in the context of SARS-CoV-2 followed by its effect on viral entry, replication, and pathogenesis. We also explored whether the spike protein furin cleavage site affected the host immune responses and SARS-CoV-2 vaccination. This review will help to provide novel insights into the effects of polybasic furin cleavage site on the current COVID-19 pandemic.

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