文献类型： 外文期刊
第一作者： Cui, Chao-Yue
作者： Cui, Chao-Yue;He, Qian;Zhang, Rong-Min;Sun, Jian;Cui, Chao-Yue;He, Qian;Zhang, Rong-Min;Feng, Youjun;Sun, Jian;Cui, Chao-Yue;He, Qian;Zhang, Rong-Min;Sun, Jian;Chen, Qiwei;Chen, Qiwei;Feng, Youjun;Chen, Qiwei;Feng, Youjun;Feng, Youjun;Sun, Jian
作者机构：
关键词： Tet(X); tetracycline; tigecycline resistance; transferability
期刊名称：WIRES MECHANISMS OF DISEASE
ISSN： 2692-9368
年卷期：
页码：
收录情况： SCI
摘要： Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology
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