Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review

文献类型： 外文期刊

第一作者： Li, Hang-Yu

作者： Li, Hang-Yu;Zhou, Dan-Dan;Huang, Si-Yu;Shang, Ao;Xu, Xiao-Yu;Li, Hua-Bin;Gan, Ren-You;Gan, Ren-You;Zhao, Cai-Ning;Shang, Ao;Xu, Xiao-Yu

作者机构：

关键词： probiotics; prebiotics; synbiotics; postbiotics; gut microbiota; obesity; type 2 diabetes mellitus; gestational diabetes mellitus; metabolic diseases

期刊名称：NUTRIENTS （ 影响因子：5.719； 五年影响因子：6.352 ）

ISSN：

年卷期： 2021 年 13 卷 9 期

页码：

收录情况： SCI

摘要： Metabolic diseases are serious threats to public health and related to gut microbiota. Probiotics, prebiotics, synbiotics, and postbiotics (PPSP) are powerful regulators of gut microbiota, thus possessing prospects for preventing metabolic diseases. Therefore, the effects and mechanisms of PPSP on metabolic diseases targeting gut microbiota are worth discussing and clarifying. Generally, PPSP benefit metabolic diseases management, especially obesity and type 2 diabetes mellitus. The underlying gut microbial-related mechanisms are mainly the modulation of gut microbiota composition, regulation of gut microbial metabolites, and improvement of intestinal barrier function. Moreover, clinical trials showed the benefits of PPSP on patients with metabolic diseases, while the clinical strategies for gestational diabetes mellitus, optimal formula of synbiotics and health benefits of postbiotics need further study. This review fully summarizes the relationship between probiotics, prebiotics, synbiotics, postbiotics, and metabolic diseases, presents promising results and the one in dispute, and especially attention is paid to illustrates potential mechanisms and clinical effects, which could contribute to the next research and development of PPSP.

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