Phytochemical Composition, Antioxidant, Antibacterial, and Enzyme Inhibitory Activities of Various Organic Extracts from Apocynum hendersonii (Hook.f.) Woodson

文献类型： 外文期刊

第一作者： Abubakar, Aminu Shehu

作者： Abubakar, Aminu Shehu;Huang, Xiaoyu;Birhanie, Ziggiju Mesenbet;Gao, Gang;Feng, Xinkang;Yu, Chunming;Chen, Ping;Chen, Jikang;Chen, Kunmei;Wang, Xiaofei;Zhu, Aiguo;Abubakar, Aminu Shehu

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关键词： Apocynum hendersonii; flavonoids; phenolics; tannins; polysaccharides; antioxidant; antimicrobial; tyrosinase; acetylcholinesterase

期刊名称：PLANTS-BASEL （ 影响因子：4.658； 五年影响因子：4.827 ）

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年卷期： 2022 年 11 卷 15 期

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收录情况： SCI

摘要： Apocynum hendersonii is a traditional medicinal plant used primarily as tea. It has a potential health benefit from its rich bioactive substances. This study investigated the reactivity of solvents of different polarities (ethanol, ethyl acetate, n-hexane, methanol, and water) extracts of the A. hendersonii leaf. The phytochemical composition of the extracts was evaluated using a Fourier Transform Infrared spectrophotometer (FT-IR), Gas Chromatography-Mass Spectrometry (GC-MS), UHPLC-MS, and Higher Performance Liquid Chromatography (HPLC). The result revealed the presence of medicinally important bioactive constituents, including phenols, flavonoids, and polysaccharides. Methanol extracts exhibited the highest flavonoid contents (20.11 +/- 0.85 mg QE/g DW) and the second-highest in terms of phenolic (9.25 +/- 0.03 mg GAE/g DW) and polysaccharide (119.66 +/- 2.65 mg GE/g DW). It also had the highest antioxidant capacity with 60.30 +/- 0.52% and 4.60 +/- 0.02 mu mol Fe2+ per g DW based on a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing antioxidant power (FRAP), respectively. Ethanol extract displayed the maximum antibacterial action against Gram-negative and Gram-positive bacteria and the highest inhibition activity against the enzymes tyrosinase and acetylcholinesterase, followed by methanol extract. The principal component analysis revealed a positive correlation between the constituents, bioactivities, and extracts. The overall result showed A. hendersonii as a rich natural source of antimicrobial and antioxidant bioactive compounds and may be used for future applications in pharmaceuticals and food industries.

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