When RING finger family proteins meet SARS-CoV-2

文献类型： 外文期刊

第一作者： Cai, Chunmei

作者： Cai, Chunmei;Cai, Chunmei;Tang, Yan-Dong;Zheng, Chunfu;Tang, Yan-Dong;Zheng, Chunfu

作者机构：

关键词： antiviral immunity; RNF family proteins; SARS-CoV-2; viral immune evasion

期刊名称：JOURNAL OF MEDICAL VIROLOGY （ 影响因子：20.693； 五年影响因子：12.203 ）

ISSN： 0146-6615

年卷期： 2022 年 94 卷 7 期

页码：

收录情况： SCI

摘要： The pandemic coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently the most formidable challenge to humankind. Understanding the complicated virus-host interplay is crucial for fighting against viral infection. A growing number of studies point to the critical roles of RING (really interesting new gene) finger (RNF) proteins during SARS-CoV-2 infection. RNF proteins exert direct antiviral activity by targeting genome and envelope glycoproteins of SARS-CoV-2. Additionally, some RNF members serve as potent regulators for antiviral innate immunity and antibody-dependent neutralization of SARS-CoV-2. Notably, SARS-CoV-2 also hijacks the RNF proteins-mediated ubiquitination process to evade host antiviral innate immunity and enhance viral replication. In this mini-review, we discuss the diverse antiviral mechanisms of RNF proteins and viral immune evasion in an RNF proteins-dependent manner. Understanding the crosstalk between RNF proteins and SARS-CoV-2 infection would help design potential novel targets for COVID-19 treatment.

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