Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups

文献类型： 外文期刊

第一作者： Zhang, Yue

作者： Zhang, Yue;Zhao, Lihui;Li, Hongyuan;Wang, Xiaohui;Jin, Sha;Lu, Yuyuan;Peng, Yinghua;Wang, Xiaohui;Wang, Xiaohui

作者机构：

关键词： Cannabidiol; Reactive oxygen species; C; elegans; Alzheimer's disease

期刊名称：EUROPEAN JOURNAL OF PHARMACOLOGY （ 影响因子：5.195； 五年影响因子：4.721 ）

ISSN： 0014-2999

年卷期： 2022 年 919 卷

页码：

收录情况： SCI

摘要： Recent discoveries have implicated the potential of Cannabidiol (CBD) in the prevention of Alzheimer's disease (AD). However, how CBD affects such neurodegenerative disorders remains unclear. Herein, Caenorhabditis elegans (C. elegans) was used as the model organism to elucidate the mechanism by which CBD ameliorates AD in vivo. CBD was found to alleviate the progression of A/3-induced AD but not tau protein-induced AD or alpha-syn-induced Parkinson's disease. CBD inhibited the aggregation of A/3 in C. elegans. However, CBD failed to prevent the formation of /3-sheet aggregation in vitro. Moreover, CBD was found to scavenge reactive oxygen species (ROS) in vivo without inducing the overexpression of antioxidative genes. In addition, CBD treatment enhanced the worm resistance to oxidative stress, which was independent of the classical transcription factors DAF-16 and SKN-1. These results supported that the in vivo antioxidative activity of CBD was most likely due to its intrinsic antioxidative property. Furthermore, the phenolic hydroxyl groups of CBD were found to be critical for scavenging ROS in vitro and in vivo, alleviating the aggregation of A/3 in vivo, and ameliorating A/3-associated neurotoxicity. These studies show that CBD protects against AD in C. elegans via the ROS scavenging activity of its phenolic hydroxyl groups, which provides insight for further structure-activity relationship studies of CBD as an AD therapeutic.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序