Natural compound Sanggenon C inhibits porcine reproductive and respiratory syndrome virus replication in piglets

文献类型： 外文期刊

第一作者： Liu, Xiao

作者： Liu, Xiao;Meng, Yinan;He, Jianyu;Jiang, Xuelian;Zhang, Shuangquan;Wang, Dan;Zhu, Yanan;Fan, Yunpeng;Yin, Yupeng;Liu, Xiao;Zheng, Zifang;Xiao, Shuqi

作者机构： Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China;Lanzhou Univ, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Chinese Acad Agr Sci,Coll Vet Med, Lanzhou 730046, Peoples R China

关键词： PRRSV; Sanggenon C; Piglets; Lung; Pathological damage

期刊名称：VETERINARY MICROBIOLOGY （ 2022影响因子：3.3； 五年影响因子：3.5 ）

ISSN： 0378-1135

年卷期： 2024 年 290 卷

页码：

收录情况： SCI

摘要： Porcine reproductive and respiratory syndrome virus is one of the main pathogens threatening the global pig industry, and there is still a lack of effective therapeutic drugs. Sanggenon C is a flavanone Diels-Alder adduct compound extracted from the root bark of the mulberry genus, which has blood pressure-reducing, antiatherosclerotic, anti-oxidative, and anti-inflammatory effects. In our previous study, Sanggenon C was confirmed to significantly inhibit PRRSV replication in vitro. However, its antiviral potential to inhibit PRRSV infection in vivo has not been evaluated in piglets. Here, the antiviral effect of Sanggenon C was evaluated in PRRSVchallenged piglets based on assessments of rectal temperature, viral load, pathological changes of lung tissue and secretion of inflammatory cytokines. The results showed that Sanggenon C treatment relieved the clinical symptoms, reduced the viral loads in the lungs and bloods, alleviated the pathological damage of lung tissue, decreased the secretion of inflammatory cytokines, and shorten the excretion time of virus from the oral and nasal secretions and feces of piglets after PRRSV infection. The results indicated that Sanggenon C is a promising anti-PRRSV drug, which provides a new strategy for the prevention and control of PRRS in clinical practice.

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