p-Terphenyl and Diphenyl Ether Derivatives from the Marine-Derived Fungus Aspergillus candidus HM5-4

文献类型： 外文期刊

第一作者： Zeng, Yanbo

作者： Zeng, Yanbo;Wang, Shirong;Peng, Hanyang;Zhao, Weibo;Chang, Wenjun;Wang, Hao;Chen, Huiqin;Dai, Haofu;Zeng, Yanbo;Wang, Shirong;Peng, Hanyang;Zhao, Weibo;Chang, Wenjun;Wang, Hao;Chen, Huiqin;Dai, Haofu;Zeng, Yanbo;Wang, Shirong;Zeng, Yanbo;Chang, Wenjun;Peng, Hanyang;Zhao, Weibo

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关键词： marine fungus; Aspergillus candidus; p-terphenyl; diphenyl ether; antifungal activity; cytotoxic activity; alpha-glucosidase inhibition

期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）

ISSN：

年卷期： 2024 年 22 卷 1 期

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收录情况： SCI

摘要： Two undescribed p-terphenyl derivatives, asperterphenylcins A-B (1-2), and two undescribed diphenyl ether derivatives, asperdiphenylcins A-B (3-4), together with three previously described p-terphenyl derivatives-4 ''-deoxyterprenin (5), terphenyllin (6), and 3 ''-hydroxyterphenyllin (7)-were obtained from the solid-rice culture of the marine-derived fungus Aspergillus candidus HM5-4, which was isolated from sponges from the South China Sea. Their structures were elucidated by HRESIMS data and NMR spectroscopic analysis. Compound 1 showed a strong inhibitory effect on Neoscytalidium dimidiatum, with an inhibition circle diameter of 31.67 +/- 2.36 mm at a concentration of 10.0 mu g/disc. Compounds 5 and 7 displayed cytotoxic activity against human chronic myeloid leukemia cells (K562), human liver cancer cells (BEL-7402), human gastric cancer cells (SGC-7901), human non-small cell lung cancer cells (A549) and human HeLa cervical cancer cells, with IC50 values ranging from 3.32 to 60.36 mu M, respectively. Compounds 2, 6 and 7 showed potent inhibitory activity against alpha-glucosidase, with IC50 values of 1.26 +/- 0.19, 2.16 +/- 0.44 and 13.22 +/- 0.55 mu M, respectively.

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