SNPs in the Galectin-8 gene of Acanthopagrus latus have been found to be associated with resistance trait to Streptococcus iniae

文献类型： 外文期刊

第一作者： Pan, Jin-Min

作者： Pan, Jin-Min;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang;Pan, Jin-Min;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang;Pan, Jin-Min;Guo, Hua-Yang;Liu, Bao-Suo;Zhang, Nan;Xian, Lin;Zhu, Teng-Fei;Zhu, Ke-Cheng;Zhang, Dian-Chang

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关键词： Acanthopagrus latus; Streptococcus iniae; SNPs; Galectin-8

期刊名称：AQUACULTURE INTERNATIONAL （ 影响因子：2.4； 五年影响因子：2.7 ）

ISSN： 0967-6120

年卷期： 2025 年 33 卷 1 期

页码：

收录情况： SCI

摘要： Seabream is one of most important candidates for aquaculture in China. However, in recent years, streptococcosis has posed a serious challenge. Galectin-8 has been proven to play an important role in the antibacterial immunity of teleost. In this study, Acanthopagrus latus Galectin-8 (AlGal-8) was characterized for the first time consisting of 8 exons and 7 introns. AlGal-8 protein was considered to dock with N-Acetylglucosamine in the CRD region. In healthy tissues, AlGal-8 was found to be expressed highest in the gills, followed by brain, kidney and liver. After infection with Streptococcus iniae, the expression of AlGal-8 in the brain, kidney, and liver increased to varying degrees, but there was no significant change in the spleen. We also analyzed SNPs present in the genomic region of AlGal-8, and a total of 8 SNPs were found. One SNPs in exon (G2264C) and two in introns (T4799G and C4892T) were significantly (P < 0.05) associated with resistance to S. iniae. This study not only provides a reference for the role of Galectin-8 in the antibacterial immunity of teleost but also provides fundamental information for the disease-resistant molecular breeding of A. latus.

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