Maduraflavacins A-E, Unusual Phenyl Polyene Metabolites Produced by a Rare Marine-Derived Actinomadura sp.

文献类型： 外文期刊

第一作者： Zou, Yan

作者： Zou, Yan;Shi, Jing;Sun, Jia Lin;Li, Ling Yu;Yan, Zhang Yuan;Jiao, Rui Hua;Guo, Zhi Kai;Guo, Zhi Kai

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）

ISSN： 0163-3864

年卷期： 2024 年 87 卷 10 期

页码：

收录情况： SCI

摘要： Phenyl polyenes comprise a small family of bacterial natural products with broad and potent bioactivities, primarily found in actinobacteria. Here we report the discovery of five new phenyl polyene metabolites, maduraflavacins A-E (1-5), from a rare, marine-derived actinobacteria strain Actinomadura glauciflava NA03286. The structures of these natural products were determined by NMR spectroscopy, HRESIMS, LC-MS/MS, and chemical derivatization. All of these new maduraflavacins feature methyl substitutions at the polyene side chain, and maduraflavacins A-C (1-3) possessed a 1-N-beta-d-glucosamine-(3 -> 1)-O-beta-d-glucopyranosyl-(3 -> 1)-O-beta-d-glucopyranosyl-(6 -> 1)-O-beta-d-glucopyranoside tetrasaccharide moiety via an amido linkage with a phenyl polyene skeleton. Compounds 1 and 2 showed weak antibacterial activities against the Gram-positive bacteria Staphylococcus aureus Sau 16339 and Micrococcus luteus, respectively.

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