Integrated Pleiotropic Gene Set Unveils Comorbidity Insights across Digestive Cancers and Other Diseases

文献类型： 外文期刊

第一作者： Wu, Xinnan

作者： Wu, Xinnan;Zheng, Wen;Wu, Xinnan;Luo, Guangwen;Dong, Zhaonian;Jia, Gengjie

作者机构：

关键词： digestive cancers; comorbidity; pleiotropic gene set; protein-protein interaction; heterogeneity in genetic predisposition; immunity-related function

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2024 年 15 卷 4 期

页码：

收录情况： SCI

摘要： Comorbidities are prevalent in digestive cancers, intensifying patient discomfort and complicating prognosis. Identifying potential comorbidities and investigating their genetic connections in a systemic manner prove to be instrumental in averting additional health challenges during digestive cancer management. Here, we investigated 150 diseases across 18 categories by collecting and integrating various factors related to disease comorbidity, such as disease-associated SNPs or genes from sources like MalaCards, GWAS Catalog and UK Biobank. Through this extensive analysis, we have established an integrated pleiotropic gene set comprising 548 genes in total. Particularly, there enclosed the genes encoding major histocompatibility complex or related to antigen presentation. Additionally, we have unveiled patterns in protein-protein interactions and key hub genes/proteins including TP53, KRAS, CTNNB1 and PIK3CA, which may elucidate the co-occurrence of digestive cancers with certain diseases. These findings provide valuable insights into the molecular origins of comorbidity, offering potential avenues for patient stratification and the development of targeted therapies in clinical trials.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Developmental innovation of inferior ovaries and flower sex orchestrated by KNOX1 in cucurbits

    作者：Dong, Zhaonian;Liu, Xiaolin;Liu, Xun;Wang, Bowen;Tian, Caihuan;Zheng, Yingying;Yu, Qiong;Sun, Jinjing;Xin, Tongxu;Yang, Xueyong;Dong, Zhaonian;Wang, Bowen;Huang, Sanwen;Guo, Xing;Shao, Wenwen;Zhong, Liyuan;Shao, Wenwen;Zhong, Liyuan;Li, Shengkang;Zhang, Bohan;Xu, Xun;Liu, Huan;Shao, Wenwen;Tian, Caihuan;Yang, Tao;Lu, Haorong;Rose, Jocelyn K. C.;Lucas, William J.;Huang, Sanwen

    关键词：

  • Synbiotic combination of 2′-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid

    作者：He, Ying;Zhang, Bo;Xin, Yu;Wang, Wenxiu;Wang, Xue;Liu, Zhuo;She, Yongbo;Guo, Rui;Liu, Zhigang;Guo, Rui;Liu, Zhigang;Liu, Zhuo;Wu, Shan;Liu, Zhigang;Jia, Gengjie

    关键词：

  • Spatial immune scoring system predicts hepatocellular carcinoma recurrence

    作者：Jia, Gengjie;He, Peiqi;Dai, Tianli;Wang, Jiabei;Sun, Mengyuan;Li, Fuling;Liu, Yao;Lim, Tony Kiat Hon;Tao, Qingping;Wang, Wei;Umar, Ahitsham;Nashan, Bjoern;Liu, Lianxin;Sun, Cheng;Jia, Gengjie;He, Peiqi;Dai, Tianli;Sun, Mengyuan;Li, Fuling;Tao, Qingping;Wang, Wei;Umar, Ahitsham;Sun, Cheng;Jia, Gengjie;He, Peiqi;Dai, Tianli;Wang, Jiabei;Sun, Mengyuan;Li, Fuling;Liu, Yao;Tao, Qingping;Wang, Wei;Jia, Gengjie;Hao, Shuxia;Goh, Denise;Wee, Felicia;Lim, Jeffrey Chun Tatt;Yeong, Joe;Lim, Tony Kiat Hon;Ngo, Nye-Thane;Zhang, Yongchang;Ding, Chen;Ding, Chen;Yeong, Joe;Yeong, Joe;Yeong, Joe

    关键词：

  • Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance

    作者：Zhang, Xin;Xu, Tianxin;Chen, Chen;Hao, Shuxia;Gao, Fei;Jia, Gengjie;Liu, Huan;Wen, Yanlong;Hu, Jielun;Nie, Shaoping;Li, Yu;Gao, Fei

    关键词：dietary fiber; disturbance score; human disease; integrative and comparative computation; microbiota disturbance; systematic analysis

  • Periodic Table of Food Initiative for generating biomolecular knowledge of edible biodiversity

    作者：Jarvis, Andy;Debouck, Daniel;Rajasekharan, Maya;Khoury, Colin;Tohme, Joe;Gallo-Franco, Jenny;Portilla, Julian;Octavio, Mariaelena;Weissgold, Lily;German, Bruce;Khoury, Colin;Herforth, Anna;Golden, Christopher D.;Ahmed, Selena;Arnaud, Elizabeth;Declerck, Fabrice;Hunter, Danny;Pawera, Lukas;Turdieva, Muhabbat;Dawid, Corinna;Hald, Christoph;Klade, Stefan;de Haan, Stef;Declerck, Fabrice;Feskens, Edith J. M.;Fogliano, Vincenzo;Hall, Robert;van Andel, Tinde;Fritz, Gayle;Hart, Robbie;Henry, Audrey;Lowe, Andrew;Huang, Sanwen;Jia, Gengjie;Yan, Jianbin;Imanbaeva, Bermet;Turner, Nancy J.;Johnson, Elizabeth;Kalaiah, Geetha;Prasad, Rajendra;Sreeman, Sheshshayee;Karboune, Salwa;La Cerva, Gina Rae;Lal, Vincent;Levy, Avraham A.;Longvah, Thingnganing;Maeda-Yamamoto, Mari;Minnis, Paul;Nuti, Marilia;Osorio, Coralia;Peter, Sonia;Quave, Cassandra;Shapiro, Howard-Yana;Srichamnong, Warangkana;Steiner, Roy;de la Parra, John;Ulian, Tiziana;Wang, Ren;de la Parra, John

    关键词：

  • Mapping the molecular landscape of Lotus japonicus nodule organogenesis through spatiotemporal transcriptomics

    作者：Ye, Keyi;Bu, Fengjiao;Dong, Zhaonian;Ma, Zhaoxu;Tang, Zhanpeng;Zhang, Yu;Lucas, William J.;Huang, Sanwen;Zheng, Jianshu;Zhong, Liyuan;Liu, Huan;Ma, Zhaoxu;Ma, Zhaoxu;Zhang, Yu;Yang, Xueyong;Xu, Xun;Liu, Huan;Wang, Ertao;Lucas, William J.;Huang, Sanwen

    关键词：

  • Progress and opportunities of foundation models in bioinformatics

    作者：Li, Qing;Hu, Zhihang;Wang, Yixuan;Li, Lei;Fan, Yimin;King, Irwin;Li, Yu;Jia, Gengjie;Wang, Sheng;Wang, Sheng;Song, Le

    关键词：foundation models; large language models; bioinformatics; artificial intelligence

微信小程序