Synthesis of alkyl beta-D-Glcp-(1 -> 3)-[beta-D-Glcp-(1 -> 6)-beta-D-Glcp-(1 -> 6)-beta-D-glucopyranosides with anti-tumor activity
文献类型: 外文期刊
第一作者: Heng, Linsen
作者: Heng, Linsen;Zhao, Qianfei;Mei, Xiangdong;Lv, Haibin;Jiang, Xiaohui;Ning, Jun
作者机构:
关键词: carbohydrate;synthesis;oligosaccharide;glycosylation;trichloroacetimidate;anti-tumor;OLIGOSACCHARIDE;LENTINAN;POLYSACCHARIDE;TRIPLE
期刊名称:LETTERS IN ORGANIC CHEMISTRY ( 影响因子:0.867; 五年影响因子:0.865 )
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年卷期:
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收录情况: SCI
摘要: Concise and effective synthesis of alkyl tetrasaccharides were achieved from the key intermediates alkyl 2,3,4-tri-benzoyl-beta-D-glucopyranoside (5) and 2,3,4,6-tetra-O-benzoyl-beta-D-glucopyranosyl-(1 -> 3)-[2,3,4,6-tetra-O-benzoyl-beta-D-glucopyranosyl-(1 -> 6)]-2,4-di-O-acetyl-alpha-D-glucopyranosyl trichloroacetimidate (6), followed by deacylation. Bioassay of the inhibition of S-180 noumenal tumors showed that alkyl tetrasaccharides could be employed as potential agent for cancer treatment.
分类号: O62
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