Screen of small fragment mutations within the sheep thyroid stimulating hormone receptor gene associated with litter size

文献类型： 外文期刊

第一作者： Li, Ming

作者： Li, Ming;Zhou, Qian;Pan, Yejun;Lan, Xianyong;Zhang, Qingfeng;Pan, Chuanying;Mao, Cui;Pan, Yejun;Zhang, Qingfeng;Mao, Cui;Zhang, Qingfeng;Mao, Cui

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关键词： Sheep; TSHR gene; nucleotide sequence variant; reproduction traits

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.271； 五年影响因子：1.697 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： The thyroid stimulating hormone receptor (TSHR), a glycoprotein hormone receptor, plays an important role in metabolic regulation and photoperiod control in the time of reproduction in birds and mammals. Previous genome-wide association studies revealed that the TSHR gene was related to reproduction and its function was identified in female reproduction, but rare studies reported the polymorphism of TSHR gene. However, the molecular mutations of the TSHR gene in sheep have not been reported so far. Herein, we explored potential polymorphisms of the sheep TSHR gene, and a 29 bp nucleotide sequence variant (rs1089565492) was identified in the AUW sheep. There were three genotypes of the 29 bp variant locus detected which named 'II' 'DD' and 'ID' been identified. Association analysis results showed the 29 bp variant was significantly associated with the litter size of the AUW sheep (p < 0.05). This finding suggests that the 29 bp nucleotide sequence variant within TSHR gene could be a candidate marker of reproduction traits for sheep breeding improving through the marker-assisted selection (MAS).

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