Genome-wide association study for numbers of vertebrae in Dezhou donkey population reveals new candidate genes

文献类型： 外文期刊

第一作者： Sun, Yan

作者： Sun, Yan;Zhao, Chang-Heng;Wang, Wen-Wen;Ning, Chao;Zhang, Qin;Li, Yu-Hua;Wang, Yong-Hui;Wang, Tian-Qi;Shi, Xiao-Yuan;Liu, Zi-Wen;Wang, Chang-Fa;Li, Hai-Jing;Wang, Ji-Jing

作者机构：

关键词： numbers of vertebrae; GWAS; genotype imputation; Dezhou donkey

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 影响因子：4.8； 五年影响因子：4.8 ）

ISSN： 2095-3119

年卷期： 2023 年 22 卷 10 期

页码：

收录情况： SCI

摘要： Numbers of vertebrae is an important economic trait associated with body size and meat productivity in animals. However, the genetic basis of vertebrae number in donkey remains to be well understood. The aim of this study was to identify candidate genes affecting the number of thoracic (TVn) and the number of lumbar vertebrae (LVn) in Dezhou donkey. A genome-wide association study was conducted using whole genome sequence data imputed from low-coverage genome sequencing. For TVn, we identified 38 genome-wide significant and 64 suggestive SNPs, which relate to 7 genes (NLGN1, DCC, SLC26A7, TOX, WNT7A, LOC123286078, and LOC123280142). For LVn, we identified 9 genome-wide significant and 38 suggestive SNPs, which relate to 8 genes (GABBR2, FBXO4, LOC123277146, LOC123277359, BMP7, B3GAT1, EML2, and LRP5). The genes involve in the Wnt and TGF-beta signaling pathways and may play an important role in embryonic development or bone formation and could be good candidate genes for TVn and LVn.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Effects of Different Light Spectra on Oxidative Stress and Nutritional Quality of the Fish Plectropomus leopardus

    作者：Li, Wensheng;Zhang, Zheng;Liu, Baoliang;Fang, Yingying;Cao, Shuquan;Li, Wenyang;Fei, Fan;Li, Wensheng;Liu, Baoliang;Sun, Yan;He, Chengbin;Zhang, Chuanxin

    关键词：light spectra; blood biochemistry; antioxidant stress; nutritional quality; Plectropomus leopardus; light spectra; blood biochemistry; antioxidant stress; nutritional quality; Plectropomus leopardus

  • Genome-Wide Identification and Expression Analysis Under Abiotic Stress of the Lipoxygenase Gene Family in Maize (Zea mays)

    作者：Li, Sinan;Hou, Shuai;Sun, Yuanqing;Sun, Minghao;Sun, Yan;Li, Xin;Li, Yunlong;Wang, Luyao;Cai, Quan;Guo, Baitao;Zhang, Jianguo

    关键词：maize; LOX; abiotic stress; gene family; expression analysis

  • Impact of Lactobacillus plantarum fermentation on jujube juice: Insights from intelligent sensory evaluation, tolerance index, and acidogenic potential

    作者：Cai, Wenchao;Fei, Liyue;Zhang, Dongsheng;Mao, Yiwen;Lu, Ziyi;Li, Yu;Wei, Suyu;Zhao, Xinxin;Zhang, Qin;Shan, Chunhui;Cai, Wenchao;Fei, Liyue;Zhang, Dongsheng;Mao, Yiwen;Lu, Ziyi;Li, Yu;Wei, Suyu;Zhao, Xinxin;Zhang, Qin;Shan, Chunhui;Cai, Wenchao;Fei, Liyue;Mao, Yiwen;Lu, Ziyi;Li, Yu;Wei, Suyu;Zhao, Xinxin;Zhang, Qin;Shan, Chunhui;Zhang, Dongsheng;Zheng, Qiangqing

    关键词：Lactobacillus plantarum; Jujube juice; Electronic nose; Electronic tongue; Tolerance index

  • Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs

    作者：Xu, Zhiting;Lin, Qing;Cai, Xiaodian;Zhong, Zhanming;Teng, Jinyan;Zeng, Haonan;Gao, Yahui;Wei, Chen;Zhou, Jun;Zhang, Wenjing;Zhang, Xiaoke;Shi, Shaolei;Wu, Jun;Diao, Shuqi;Liu, Yuqiang;Pan, Xiangchun;Feng, Xueyan;Liu, Ruiqi;Su, Zhanqin;Chang, Chengjie;Zhu, Qianghui;Wu, Yuwei;Zhang, Hao;Yuan, Xiaolong;Li, Jiaqi;Zhang, Zhe;Li, Bingjie;Gao, Yahui;Liu, George E.;Gao, Yahui;Ma, Li;Cai, Zexi;Bai, Zhonghao;Su, Guosheng;Sahana, Goutam;Lund, Mogens Sando;Fang, Lingzhao;Wang, Xiaoqing;Shi, Liangyu;Zhao, Fuping;Wang, Xue;Wang, Yi;Zhang, Zipeng;Ding, Xiangdong;Lin, Yu;Tang, Guoqing;Li, Mingzhou;Li, Xuewei;Liu, Shuli;Yin, Hongwei;Bai, Lijing;Li, Kui;Zhou, Zhongyin;Wang, Qishan;Pan, Yuchun;Xu, Zhong;Peng, Xianwen;Mei, Shuqi;Mo, Delin;Liu, Xiaohong;Chen, Yaosheng;Liu, Yang;Xiang, Ruidong;Xiang, Ruidong;Shen, Xia;Shen, Xia;Shen, Xia;Li, Pinghua;Huang, Ruihua;Li, Pinghua;Huang, Ruihua;Ballester, Maria;Crespo-Piazuelo, Daniel;Amills, Marcel;Clop, Alex;Amills, Marcel;Karlskov-Mortensen, Peter;Fredholm, Merete;Zhang, Qin;Zhao, Yunxiang

    关键词：pig; meta-GWAS; PigGTEx; molQTL; complex traits

  • EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research

    作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang

    关键词：metagenome; microbiome; microbiota; pipeline; visualization

  • Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation

    作者：Sun, Yan;Yan, Fang;Sun, Yan;Wu, Jiajing;Shen, Beilei;Luo, Rongbo;Zhang, Shijun;Li, He;Qian, Bingshuo;Fan, Lingjun;Zhang, Junkui;Wang, Tiecheng;Xia, Xianzhu;Gao, Yuwei;Yang, Hengzheng;Cui, Huizi;Han, Weiwei;Xia, Xianzhu

    关键词：TRPV4; anti-influenza; machine learning; repurposing drugs; molecular docking

  • EIDD-2801 resists to infection and co-infection of SARS-CoV-2 and influenza virus

    作者：Qian, Bingshuo;Luo, Rongbo;Shen, Beilei;Fan, Lingjun;Zhang, Junkui;Zhang, Shijun;Sun, Yan;Deng, Xiuwen;Gao, Yuwei;Qian, Bingshuo;Zhang, Junkui;Pang, Xiaobin;Zhong, Wu

    关键词：Antiviral activity; Respiratory viruses; Influenza; SARS-CoV-2; EIDD-2801; Co-infection.

微信小程序