Characterization of polyvinyl alcohol/chitosan nanofibers loaded with royal jelly by blending electrospinning for potential wound dressings

文献类型： 外文期刊

第一作者： Yu, Hongying

作者： Yu, Hongying;Peng, Zhengju;Jiang, Han;Xiao, Chaogeng;Yu, Hongying;Chen, Di;Lu, Wenjing;Zhang, Cen;Wang, Haiyan;Peng, Zhengju;Xiao, Chaogeng

作者机构：

关键词： Bee product; Polyvinyl alcohol (PVA); Chitosan (CS); Electrospinning; Nanofiber membrane; Antimicrobial

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 307 卷

页码：

收录情况： SCI

摘要： This study aimed to fabricate a polyvinyl alcohol/chitosan (PVA/CS) nanofiber loaded with royal jelly (RJ) using blending electrospinning for potential wound dressings. The different PVA/CS ratios in electrospun nanofibers resulted in continuous nanofibers with an average diameter ranging from 219 to 299 nm. The FTIR spectra indicated that RJ was successfully incorporated into the nanofibers through hydrogen bonding with PVA/CS, which was further confirmed by the subsequent TGA experiments. Meanwhile, the RJ/PVA/CS nanofibers exhibited excellent water vapor permeability and hydrophilic properties. The encapsulation efficiency of RJ reached the maximum value of 89.00 %, while the cumulative release rate was up to 84.87 %. Furthermore, the RJ/PVA/CS nanofibers could inhibit the growth of Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). The optimal PVA/CS ratio was determined to be 7:3, achieving inhibition rates of 97.83 % for S. aureus and 72.08 % for E. coli, demonstrating an excellent antibacterial performance. Therefore, this study successfully fabricated a wound dressing nanofiber with potential antibacterial efficacy.

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