Sericin from Fibroin-Deficient Silkworms Served as a Promising Resource for Biomedicine

文献类型： 外文期刊

第一作者： Li, Yurong

作者： Li, Yurong;Wei, Yongkang;Zhang, Guozheng;Zhang, Yeshun;Li, Yurong;Zhang, Guozheng;Zhang, Yeshun;Zhang, Yeshun

作者机构：

关键词： sericin; fibroin-deficient silkworm; biomaterials; tissue engineering; drug delivery; cosmetics

期刊名称：POLYMERS （ 影响因子：5.0； 五年影响因子：5.0 ）

ISSN：

年卷期： 2023 年 15 卷 13 期

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收录情况： SCI

摘要： Sericin, a fascinating natural biomaterial derived from silkworms, has received increasing interest in recent years for its unique bioactivity and high compatibility. Silkworms can be divided into wild-type or silk fibroin-deficient mutants according to whether they synthesize and secrete silk fibroin. Silk fibroin-deficient mutant silkworms and their cocoons are convenient for us to obtain diverse and high-quality sericin, which has been applicated in various fields such as cell culture, tissue engineering, drug delivery, and cosmetics. Here, we present an overview of our silkworm varieties resources, especially silk fibroin-deficient mutant silkworms. We optimized various extraction methods of sericin and summarized the characteristics and advantages of sericin. Finally, we developed and discussed a series of sericin-based biomaterials for promising applications for a diverse set of needs.

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