Evolution of the germline mutation rate across vertebrates

文献类型： 外文期刊

第一作者： Bergeron, Lucie A.

作者： Bergeron, Lucie A.;Stiller, Josefin;Zhang, Guojie;Besenbacher, Soren;Zheng, Jiao;Li, Panyi;Zheng, Jiao;Bertelsen, Mads Frost;Quintard, Benoit;Hoffman, Joseph I.;Hoffman, Joseph I.;Li, Zhipeng;Leger, Judy St;Shao, Changwei;Gilbert, M. Thomas P.;Gilbert, M. Thomas P.;Schierup, Mikkel H.;Zhang, Guojie;Zhang, Guojie;Zhang, Guojie

作者机构：

期刊名称：NATURE （ 影响因子：64.8； 五年影响因子：60.9 ）

ISSN： 0028-0836

年卷期： 2023 年 615 卷 7951 期

页码：

收录情况： SCI

摘要： The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself1. However, little is known about what determines its evolution, as most studies of mutation rates have focused on single species with different methodologies2. Here we quantify germline mutation rates across vertebrates by sequencing and comparing the high-coverage genomes of 151 parent- offspring trios from 68 species of mammals, fishes, birds and reptiles. We show that the per-generation mutation rate varies among species by a factor of 40, with mutation rates being higher for males than for females in mammals and birds, but not in reptiles and fishes. The generation time, age at maturity and species-level fecundity are the key life-history traits affecting this variation among species. Furthermore, species with higher long-term effective population sizes tend to have lower mutation rates per generation, providing support for the drift barrier hypothesis3. The exceptionally high yearly mutation rates of domesticated animals, which have been continually selected on fecundity traits including shorter generation times, further support the importance of generation time in the evolution of mutation rates. Overall, our comparative analysis of pedigree-based mutation rates provides ecological insights on the mutation rate evolution in vertebrates.

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