Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on alpha-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge

文献类型： 外文期刊

第一作者： Chen, Juncheng

作者： Chen, Juncheng;Chen, Juncheng;Lan, Meijuan;Zhang, Xia;Li, Bing;Jiao, Wenjuan;Chen, Zhiyi;Li, Lin

作者机构：

关键词： polysaccharide; Anemarrhena asphodeloides Bunge; salivary-gastrointestinal digestion; gut microbiota

期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）

ISSN：

年卷期： 2023 年 15 卷 8 期

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收录情况： SCI

摘要： The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory alpha-glucosidase activity, and human gut microbiota. The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released. This indicates that, under a simulated digestive condition, AABP-2B is not degraded and can be further utilized by gut microbiota. AABP-2B still possessed good inhibitory activity on alpha-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion. Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera. AABP-2B can also modify the intestinal flora composition by inhibiting pathogen growth. Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation. These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.

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