Investigation of Antifungal Activity and Assessment of Resistance Risk of Fungicide Benzovindiflupyr in Pyricularia oryzae

文献类型： 外文期刊

第一作者： Sun, Yang

作者： Sun, Yang;Liu, Xinyan;He, Ziyun;Tian, Guoqi;Liu, Weiye;Chen, Xing;Chen, Yu;Sun, Yang;Chen, Xing;Chen, Yu;Ying, Jinfeng;Gu, Chunyan;Chen, Yu

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关键词： benzovindiflupyr; Pyricularia oryzae; succinate dehydrogenase inhibitors; resistancerisk and mechanism

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 19 期

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收录情况： SCI

摘要： Rice blast is a destructive disease caused by Pyricularia oryzae, which threatens global staple food production. This study aims to investigate antifungal activity and assess the resistance risk of benzovindiflupyr in P. oryzae. The mean EC50 value of benzovindiflupyr against 102 P. oryzae strains was 0.0395 mu g/mL. After benzovindiflupyr treatment, mycelia and conidia became abnormal. The effectiveness of benzovindiflupyr was markedly greater compared to the commonly used fungicides pydiflumetofen, fenoxanil, and difenoconazole at the same concentration. Eleven benzovindiflupyr-resistant mutants were obtained with a resistance frequency of 9 x 10-4 through fungicide generation. In addition, these mutants showed a fitness penalty and cross-resistance with other succinate dehydrogenase inhibitor fungicides, such as fluxapyroxad and penflufen. Point mutations H245Y/D/L and N203H in PoSdhB, S77N in PoSdhC, and D122N/G in PoSdhD were identified in benzovindiflupyr-resistant mutants, which was confirmed by molecular docking. These results suggested a moderate resistance risk associated with benzovindiflupyr in P. oryzae.

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