Stachybotrins G and H, Two New Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum

文献类型： 外文期刊

第一作者： Wang, Yi

作者： Wang, Yi;Xing, Qiao;Zhang, Tao;Chen, Kang;Xu, Yuquan

作者机构：

关键词： Stachybotrys chartarum; Stachybotryaceae; phenylspirodrimane derivatives; N-isobutyl group; antibacterial activity

期刊名称：PLANTA MEDICA （ 影响因子：2.0； 五年影响因子：2.7 ）

ISSN： 0032-0943

年卷期： 2025 年 91 卷 10/11 期

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收录情况： SCI

摘要： Two new phenylspirodrimane derivatives, designated as stachybotrins G and H (1 and 2), which feature an N-isobutyl side chain, along with four known analogues (3-6), were isolated from the fungus Stachybotrys chartarum. All the structures were determined through comprehensive spectroscopic analyses, primarily based on HRESIMS and NMR data. The antibacterial activity of all isolated compounds was evaluated. Compound 5 demonstrated antibacterial activity against the Gram-positive bacterium Staphylococcus aureus ATCC 6538, with a minimum inhibitory concentration (MIC) value of 6.25 mu g/mL.

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