Neutrophil Extracellular Traps (NETs) in Sterile Inflammatory Diseases

文献类型： 外文期刊

第一作者： Ji, Yin-Min

作者： Ji, Yin-Min;Li, Tao;Qin, Yu-Hui;Xiao, Shu-Yan;Lv, Ya-Hui;Dong, Yi;Cui, Xiao-Ran;Hu, Yi;Ji, Yin-Min;Ji, Yin-Min;Li, Tao;Qin, Yu-Hui;Xiao, Shu-Yan;Lv, Ya-Hui;Dong, Yi;Cui, Xiao-Ran;Hu, Yi;Li, Tao;Li, Tao;Cui, Xiao-Ran;Hu, Yi

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关键词： neutrophils; extracellular traps; autoimmune diseases; sterile inflammation; immune checkpoint inhibitors; ICIs

期刊名称：JOURNAL OF INFLAMMATION RESEARCH （ 影响因子：4.1； 五年影响因子：4.5 ）

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年卷期： 2025 年 18 卷

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收录情况： SCI

摘要： Neutrophil Extracellular Traps (NETs) are fibrous web-like structures released by neutrophils in response to pathogenic infections or inflammatory stimuli. Composed of decondensed chromatin DNA, histones, and granular proteins, NETs primarily function to eliminate pathogens through physical entrapment and biochemical cytotoxicity. However, they may also contribute to the pathogenesis of inflammatory diseases. While NETs played an important role in pathogen defense, their non-specific components can also damage surrounding tissues, exacerbating inflammation. The role and mechanisms of NETs in various diseases have been well-documented, including autoimmune diseases, cancer, and infectious diseases. This review aims to elaborate on the mechanisms by which NETs mediate sterile inflammation.

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