A rapid solid-phase extraction purification combined with UPLC-MS/MS used for simultaneous determination of eight tetracyclines and three metabolite in chicken and pork

文献类型： 外文期刊

第一作者： Gao, Pengfei

作者： Gao, Pengfei;Chen, Lan;Ding, Hao;Xie, Kaizhou;Gao, Pengfei;Xie, Xing;Gao, Pengfei;Guo, Yawen;Chen, Lan;Ding, Hao;Xu, Junjie;Liu, Shuyu;Zhu, Yali;Zhang, Tao;Xie, Kaizhou;Guo, Yawen;Xu, Junjie;Liu, Shuyu;Zhu, Yali;Zhang, Tao;Xie, Kaizhou;Xie, Xing

作者机构：

关键词： Tetracycline antibiotics; Chicken; Pork; Residues; UPLC-MS/MS

期刊名称：JOURNAL OF FOOD COMPOSITION AND ANALYSIS （ 影响因子：4.3； 五年影响因子：4.6 ）

ISSN： 0889-1575

年卷期： 2024 年 132 卷

页码：

收录情况： SCI

摘要： A method for rapid detection and identification of 8 tetracyclines (TCs) and 3 metabolite residues in chicken and pork was established and verified by combining rapid solid-phase extraction (SPE) technology with ultrahighperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After a sample was extracted, it was purified with a PRiME HLB cartridge, and the cartridge did not need to be activated, balanced, or eluted. The filtrate was dried under nitrogen, redissolved, and subsequently analyzed via UPLC-MS/MS. The limits of detection for chicken and pork were 0.05-0.48 mu g/kg and 0.05-0.52 mu g/kg, respectively. The limits of quantification were 0.16-1.61 mu g/kg and 0.16-1.75 mu g/kg, respectively. The recoveries were 85.15%-107.50% and 84.21%-106.37%, respectively. The established method was suitable for qualitative and quantitative analyses of TCs and their metabolite residues in chicken and pork and has been used for the detection of TC in chicken and pork samples from local markets.

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