Genomic prediction of carcass traits using different haplotype block partitioning methods in beef cattle

文献类型： 外文期刊

第一作者： Li, Hongwei

作者： Li, Hongwei;Wang, Zezhao;Xu, Lei;Li, Qian;Gao, Han;Ma, Haoran;Cai, Wentao;Chen, Yan;Gao, Xue;Zhang, Lupei;Gao, Huijiang;Zhu, Bo;Xu, Lingyang;Li, Junya

作者机构：

关键词： Bayesian models; beef cattle; GBLUP; haplotype; linkage disequilibrium

期刊名称：EVOLUTIONARY APPLICATIONS （ 影响因子：4.929； 五年影响因子：5.453 ）

ISSN： 1752-4571

年卷期： 2022 年 15 卷 12 期

页码：

收录情况： SCI

摘要： Genomic prediction (GP) based on haplotype alleles can capture quantitative trait loci (QTL) effects and increase predictive ability because the haplotypes are expected to be in linkage disequilibrium (LD) with QTL. In this study, we constructed haploblocks using LD-based and the fixed number of single nucleotide polymorphisms (fixed-SNP) methods with Illumina BovineHD chip in beef cattle. To evaluate the performance of different haplotype block partitioning methods, we constructed haploblocks based on LD thresholds (from r(2) > 0.2 to r(2) > 0.8) and the number of fixed-SNPs (5, 10, 20). The performance of predictive methods for three carcass traits including liveweight (LW), dressing percentage (DP), and longissimus dorsi muscle weight (LDMW) was evaluated using three approaches (GBLUP and BayesB model based on the SNP, G(H)BLUP, and BayesBH models based on the haploblock, and G(H)BLUP+GBLUP and BayesBH+BayesB models based on the combined haploblock and the nonblocked SNPs, which were located between blocks). In this study, we found the accuracies of LD-based and fixed-SNP haplotype Bayesian methods outperformed the Bayesian models (up to 8.54 +/- 7.44% and 5.74 +/- 2.95%, respectively). G(H)BLUP showed a high improvement (up to 11.29 +/- 9.87%) compared with GBLUP. The Bayesian models have higher accuracies than BLUP models in most scenarios. The average computing time of the BayesBH+BayesB model can reduce by 29.3% compared with the BayesB model. The prediction accuracies using the LD-based haplotype method showed higher improvements than the fixed-SNP haplotype method. In addition, to avoid the influence of rare haplotypes generated from haplotype construction, we compared the performance of GP by filtering four types of minor haplotype allele frequency (MHAF) (0.01, 0.025, 0.05, and 0.1) under different conditions (LD levels were set at r(2) > 0.3, and the fixed number of SNPs was 5). We found the optimal MHAF threshold for LW was 0.01, and the optimal MHAF threshold for DP and LDMW was 0.025.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序