文献类型： 外文期刊
第一作者： Chen, Quan-Bing
作者： Chen, Quan-Bing;Zhu, Shuai;Dong, Zhi-Jun;Gu, Hua-Zhi;Zou, Tao;Shen, Mei-Hua;Yuan, Qiong;Ren, Xiao-He;Zhang, Xian-Zheng;Shang, Jin-Ting;Liu, Wei;Zhang, Zhao-Wei
作者机构：
期刊名称：JOURNAL OF MATERIALS CHEMISTRY B （ 影响因子：7.571； 五年影响因子：6.788 ）
ISSN： 2050-750X
年卷期： 2022 年 10 卷 27 期
页码：
收录情况： SCI
摘要： Tumor-triggered targeting ammonium bicarbonate (TTABC) liposomes were proposed to improve the uptake of ammonium bicarbonate (ABC) liposomes in tumor cells and retain their long circulation in vivo in our previous study. However, it must be solved how to precisely release the loaded drugs of the TTABC liposomes into tumor cells. In addition, synergistic multimodal therapy could result in better tumor treatment outcomes than monomodal chemotherapy. In the research, we prepared indocyanine green (ICG) and doxorubicin (DOX) encapsulated TTABC liposomes (ICG&DOX@TTABC) to achieve near-infrared (NIR) light-controlled chemo/photothermal/photodynamic multimodal therapy guided by fluorescence and photothermal imaging. In vitro and vivo studies show that ICG&DOX@TTABC can specifically accumulate in tumor tissues, effectively transform NIR light into local thermo-therapy, and have excellent anti-tumor ability without obvious side effects. ICG&DOX@TTABC could be promising for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic tumor treatment.
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