Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway

文献类型： 外文期刊

第一作者： Hu, Chengjun

作者： Hu, Chengjun;Wu, Zifang;Huang, Zihao;Hao, Xiangyu;Wang, Shuqi;Deng, Jinping;Tan, Chengquan;Hu, Chengjun;Yin, Yulong

作者机构：

关键词： Angiogenesis; IUGR; Nox2; Placenta; STAT3; VEGF-A

期刊名称：REDOX BIOLOGY （ 影响因子：11.799； 五年影响因子：12.038 ）

ISSN： 2213-2317

年卷期： 2021 年 45 卷

页码：

收录情况： SCI

摘要： Aberrant placental angiogenesis is associated with fetal intrauterine growth restriction (IUGR), but the mechanism underlying abnormal placental angiogenesis remains largely unknown. Here, lower vessel density and higher expression of NADPH oxidases 2 (Nox2) were observed in the placentae for low birth weight (LBW) fetuses versus normal birth weight (NBW) fetuses, with a negative correlation between Nox2 and placental vessel density. Moreover, it was revealed for the first time that Nox2 deficiency facilitates angiogenesis in vitro and in vivo, and vascular endothelial growth factor-A (VEGF-A) has an essential role in Nox2-controlled inhibition of angiogenesis in porcine vascular endothelial cells (PVECs). Mechanistically, Nox2 inhibited phospho-signal transducer and activator of transcription 3 (p-STAT3) in the nucleus by inducing the production of mitochondrial reactive oxygen species (ROS). Dual-luciferase assay confirmed that knockdown of Nox2 reduces the expression of VEGF-A in an STAT3 dependent manner. Our results indicate that Nox2 is a potential target for therapy by increasing VEGF-A expression to promote angiogenesis and serves as a prognostic indicator for fetus with IUGR.

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