The ZmWAKL-ZmWIK-ZmBLK1-ZmRBOH4 module provides quantitative resistance to gray leaf spot in maize

文献类型： 外文期刊

第一作者： Zhong, Tao

作者： Zhong, Tao;Zhu, Mang;Zhang, Qianqian;Deng, Suining;Guo, Chenyu;Xu, Ling;Liu, Tingting;Xu, Mingliang;Zhang, Yan;Xu, Ling;Liu, Tingting;Li, Yancong;Bi, Yaqi;Fan, Xingming;Balint-Kurti, Peter;Balint-Kurti, Peter;Xu, Mingliang

作者机构：

期刊名称：NATURE GENETICS （ 影响因子：30.8； 五年影响因子：37.4 ）

ISSN： 1061-4036

年卷期： 2024 年 56 卷 2 期

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收录情况： SCI

摘要： Gray leaf spot (GLS), caused by the fungal pathogens Cercospora zeae-maydis and Cercospora zeina, is a major foliar disease of maize worldwide (Zea mays L.). Here we demonstrate that ZmWAKL encoding cell-wall-associated receptor kinase-like protein is the causative gene at the major quantitative disease resistance locus against GLS. The ZmWAKL(Y) protein, encoded by the resistance allele, can self-associate and interact with a leucine-rich repeat immune-related kinase ZmWIK on the plasma membrane. The ZmWAKL(Y)/ZmWIK receptor complex interacts with and phosphorylates the receptor-like cytoplasmic kinase (RLCK) ZmBLK1, which in turn phosphorylates its downstream NADPH oxidase ZmRBOH4. Upon pathogen infection, ZmWAKL(Y) phosphorylation activity is transiently increased, initiating immune signaling from ZmWAKL(Y), ZmWIK, ZmBLK1 to ZmRBOH4, ultimately triggering a reactive oxygen species burst. Our study thus uncovers the role of the maize ZmWAKL-ZmWIK-ZmBLK1-ZmRBOH4 receptor/signaling/executor module in perceiving the pathogen invasion, transducing immune signals, activating defense responses and conferring increased resistance to GLS.

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