Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura

文献类型： 外文期刊

第一作者： Li, Zong-Nan

作者： Li, Zong-Nan;Zhang, Yu-Xuan;Zhang, Zhi-Ang;Pan, Lian-Han;Li, Ping;Xu, Yan;Sheng, Sheng;Wu, Fu-An;Wang, Jun;Li, Ping;Xu, Yan;Sheng, Sheng;Wu, Fu-An;Wang, Jun

作者机构：

关键词： Microfluidic; Phoxim; Nanoemulsion; Cloud point/boiling point; Feeding toxicity; Contact killing; Spodoptera litura

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：5.19； 五年影响因子：5.053 ）

ISSN： 0944-1344

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页码：

收录情况： SCI

摘要： With continuous development of pesticide dosage forms, emulsifiable concentrates using large amounts of organic solvents are gradually obsoleted. Nanoemulsions with high water content have been developed and the preparation processes also evolved, but these processes still exist some problems, such as poor controllability and high energy consumption. Microfluidic is a controllable nanoemulsion preparation system which mainly applied to pharmaceutical synthesis. In this study, the pesticide phoxim nanoemulsion was prepared by microfluidic technology. The optimized formulation of phoxim nanoemulsion was composed of Tween 80 and pesticide emulsifier 500 as surfactant, hexyl acetate as oil, and n-propanol as co-surfactant. Moreover, when the flow rates of water and oil in the microfluidic system were adjusted to 5 mu L/min and 20 mu L/min, phoxim nanoemulsion was obtained with a cloud point/boiling point of 109 degrees C, a particle size of 21.5 +/- 0.8 nm and a potential value of -18.7 +/- 0.6 mV. Furthermore, the nanoemulsion had a rapid release effect in vitro which could be fitted by the Ritger-Peppas model. The feeding toxicity of the phoxim nanoemulsion was higher than that of commercial formulation while the contact killing effect was higher than that of the active ingredient. Therefore, pesticide dosage was reduced and the insecticidal effect was enhanced by using phoxim nanoemulsions. These results also confirm the potential of microfluidics as a green process to produce pesticide nanoemulsions.

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