Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee?

文献类型： 外文期刊

第一作者： Wu, X

作者： Wu, X;Skog, K;Jagerstad, M

作者机构：

关键词： Alkaloids;Coffee;Mutagens;生物碱类;咖啡;诱变剂

期刊名称：MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS （ 影响因子：2.873； 五年影响因子：2.69 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Trigonelline and amino acids are natural components in green coffee beans. Model systems mimicking coffee roasting were used to produce heated samples of trigonelline, amino acids and glucose. Trigonelline and amino acids were heated separately or in combinations for 20 min at 250 degrees C. The results of bacteria mutation assays (Salmonella typhimurium strains TA 98, YG 1024 and YG 1029) showed that trigonelline, alone or in combination with most of the single amino acids and mixtures of amino acids, yielded potent mutagenic activity. Of the singly heated compounds, the highest mutagenic activity was found for trigonelline. The mutagenic activity detected with metabolic activation of the heated trigonelline samples indicated that the mutagenic compounds might be amines; however, higher mutagenic activity was found for trigonelline and its combinations without metabolic activation, which suggests that other types of mutagens (direct-acting) were predominant. High-performance liquid chromatographic analysis of some of the heated samples did not reveal the presence of any known mutagenic heterocyclic amine.

分类号： R3

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