Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.

文献类型： 外文期刊

第一作者： Zhao, You-Xing

作者： Zhao, You-Xing;Ma, Qing-Yun;Dai, Hao-Fu;Fan, Hui-Jin;Tian, Wei-Xi;Ma, Xiao-Feng;Liang, Wen-Juan;Jiang, He-Zhong;Li, Ning

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期刊名称：CARBOHYDRATE RESEARCH （ 影响因子：2.104； 五年影响因子：2.192 ）

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收录情况： SCI

摘要： Natural products inhibiting fatty acid synthase (FAS) are appearing as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Nephelium lappaceum L. resulted in the isolation of ten compounds (1-10) mainly including flavonoids and oleane-type triterpene oligoglycosides, in which all of the compounds were isolated from this plant for the first time. Additionally, compounds 8 and 9 were new hederagenin derivatives and were elucidated as hederagenin 3-O-(2,3-di-O-acetyl- α-L-arabinofuranosyl)-(1→3)-[α-L-rhamnopyranosyl(1→2)] -β-L-arabinopyranoside and hederagenin 3-O-(3-O-acetyl-α-L- arabinofuranosyl)-(1→3)-[α-L-rhamnopyranosyl-(1→2)] -β-L-arabinopyranoside, respectively. All these isolates were evaluated for inhibitory activities of FAS, which showed these isolates had inhibitory activity against FAS with IC_(50) values ranging from 6.69 to 204.40 μM, comparable to the known FAS inhibitor EGCG (IC_(50) = 51.97 μM). The study indicates that the hulls of Nephelium lappaceum L. could be considered as potential sources of promising FAS inhibitors and the oleane-type triterpene oligoglycosides could be considered as another type of natural FAS inhibitors.

分类号： O62

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