Effects of Enterococcus faecium (SF68) on immune function in mice

文献类型: 外文期刊

第一作者: Sun, Peng

作者: Sun, Peng;Wang, Jiaqi;Jiang, Yanmei;Sun, Peng

作者机构:

关键词: enterococcus faecium;intestinal microbiota;lymphocyte subsets;antibody;cytokines;mice

期刊名称:FOOD CHEMISTRY ( 影响因子:7.514; 五年影响因子:7.516 )

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收录情况: SCI

摘要: Probiotics exert health benefits on human and animals when administered in adequate amounts. The objective of this study was to assess the effects of Enterococcus faecium (SF68) on intestinal colonisation and immune function of BALB/c mice. Six-week-old female BALB/c mice were orally administered with E. faecium (SF68). Results showed that the total anaerobe and lactobacilli in the faeces increased (P< 0.05), while the number of faecal enterobacteria decreased (P< 0.05) in E aecium-fed mice. Furthermore, supplementation of E. faecium (SF68) increased the percentage of double positive (DP) cells in peripheral blood, the concentration of plasma IgG, and the levels of interleukin-4 (1L-4), interleukin-6 (IL-6) and interferon-γ (IFN-γ) in splenocytes of the mice (P< 0.05). This study demonstrated that E. faecium SF68 affects the intestinal microbial flora and modulates the immune responses, which indicates a viable pro-biotic characteristic of E. faecium SF68 in modification of immune function.

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