A substitution within erythropoietin receptor gene D1 domain associated with litter size in Beijing Black pig, Sus scrofa

文献类型： 外文期刊

第一作者： Zhang, Longchao

作者： Zhang, Longchao;Wang, Ligang;Li, Yong;Li, Wen;Yan, Hua;Liu, Xin;Zhao, Kebin;Wang, Lixian

作者机构：

关键词： erythropoietin receptor: D1 domain;cysteine residue;litter size;allele frequency;uterine capacity;fetal survivability

期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.749； 五年影响因子：1.909 ）

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收录情况： SCI

摘要： Studies of uterine capacity and litter size in swine have suggested that erythropoietin receptor (EPOR) plays an important role in fetal survival through maturation of red blood cells. In this study, we screened the porcine EPOR gene for mutations and identified three single nucleotide polymorphisms (SNPs): two missense mutations and one synonymous mutation. We then genotyped 272 Beijing Black sows, Sus scrofa, and compared this data with litter sizes from a total of 1523 parities among the sows. The G allele of the nonsynonymous SNP, EPOR c.434A>G, was associated with greater litter size at both first parity (P < 0.05) and at later parities (P < 0.01). This SNP causes His92Arg adjacent to the fourth conserved cysteine residue in the mature protein and is in the D1 domain of the protein. Additionally, we determined the allele frequencies for this SNP among six Chinese indigenous pig breeds (Bamei, Erhualian, Laiwu Black, Mashen, Meishan and Min) and three Western commercial pig breeds (Duroc, Landrace and Large White). The c.434G allele was significantly more common among the more prolific Chinese breeds than the Western breeds, implying that EPOR c.434A>G could be a useful genetic marker to improve litter size in swine.

分类号： S8

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