Schistosoma japonicum: Treatment of different developmental stages in mice with long-acting praziquantel implants

文献类型： 外文期刊

第一作者： Cheng, Liang

作者： Cheng, Liang;Lei, Lei;Guo, Shengrong;Rong, Haojun;Guo, Dongwei;Zhu, Chuangang;Zhang, Lei;Jiang, Yan;Lin, Jiaojiao

作者机构：

关键词： praziquantel: PZQ;55268-74-1;antiinfective-drug;antiparasitic-drug;pharmacodynamics;pharmacokin;cell aggregation;different developmental stage

期刊名称：EXPERIMENTAL PARASITOLOGY （ 影响因子：2.011； 五年影响因子：2.132 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： This paper reports the effective treatment of Schistosoma japonicum in a mouse model with long-acting praziquantel (PZQ)-loaded poly(epsilon-caprolactone) implants. The implants yielded stable, high plasma PZQ concentrations ranging 100-1600 ng/mL during the 40-day investigation period. For assessment of efficacy, the implants were implanted into mice immediately after infection and at 1, 2, 3 and 4 weeks after infection to treat the schistosomes at different developmental stages. All the mice were sacrificed at 6 weeks after infection for worm and egg recovery, worm morphology examination, and histopathological analysis of implantation site tissues. The worm burdens, egg burdens, and numbers of miracidia hatched from the retrieved eggs for all the implant-treated groups (except groups T2-A, T4 and T5) were reduced by 100% when compared with the control group. From groups T2-A, T4 and T5, some schistosome debris was recovered. Eggs were found in only group 15 for which the time between infection and implantation was 4 weeks, which enabled the maturation of juvenile female schistosomes into adult ones that lay eggs. Histopathological observations of implantation tissue showed no evidence of granulomatous foreign-body or lymphoid cell aggregation, demonstrating good biocompatibility of the PZQ implants. These results demonstrate that the long-acting PZQ implants can kill schistosomes at any developmental stages and attenuate/avoid the associated liver damage

分类号： Q958.9

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