Isolation of an anti-tumor polysaccharide from Auricularia polytricha (Jew's ear) and its effects on macrophage activation

文献类型： 外文期刊

第一作者： Qing, Yuan

作者： Qing, Yuan;Yang, Zhirong;Zheng, Linyong;Zheng, Linyong;Yu, Mengyao;Xu, Xiaoyan;Qing, Yuan;Luo, Xia

作者机构：

关键词： Auricularia polytricha;Polysaccharides;Anti-tumor;Macrophage activation;Cytokine;NO

期刊名称：EUROPEAN FOOD RESEARCH AND TECHNOLOGY （ 影响因子：2.998； 五年影响因子：3.005 ）

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收录情况： SCI

摘要： To investigate the active compound and its mechanism of the anti-tumor effects of Auricularia polytri-cha, the polysaccharides were isolated and its effects on macrophages were tested. By alcohol-precipitation, DEAE-cellulose ion exchange, gel permeation chromatography and in vivo anti-tumor test on the sarcoma 180 tumor-bearing mice, a fraction of polysaccharides (namely APPIIA) with significant anti-tumor effect was isolated. APPIIA can enhance the neutral red phagocytosis of macrophages. It can also stimulate the nitric oxide (NO) release and cytokines secretion of macrophage in a dose-dependent manner. By quantitative RT-PCR method, it can be found that APPIIA can augment the mRNA transcription of inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, interleukin (IL)-l beta and IL-6. The results of western blotting showed that it can also increased the protein expression of iNOS. These results suggest that APPIIA is one of effective anti-tumor agents and its anti-tumor effect may exhibit via the macrophage activation.

分类号： R15

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