A bursal pentapeptide (BPP-I), a novel bursal-derived peptide, exhibits antiproliferation of tumor cell and immunomodulator activity

文献类型： 外文期刊

第一作者： Feng, Xiu L.

作者： Feng, Xiu L.;Liu, Qing T.;Cao, Rui B.;Wang, Fang Q.;Deng, Wen L.;Zhang, Yu;Ishag, Hassan;Chen, Pu Y.;Liu, Qing T.;Qiu, Ya F.;Ma, Zhi Y.;Zheng, Qi S.

作者机构：

关键词： Bursal pentapeptide;Antiproliferation on tumor cell;Antitumor factor p53;Hybridoma cell;Immunodominant functions

期刊名称：AMINO ACIDS （ 影响因子：3.52； 五年影响因子：3.6 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. Here, we isolated a novel bursal pentapeptide I (BPP-I), LGPGP, from BF. BPP-I could play inhibition effect on MCF-7 but not on CEF or Vero cell proliferation in vitro, and enhance antitumor factor p53 protein expression. Also, BPP-I stimulated antibody production in a dose-dependent manner in hybridoma cell. Furthermore, BPP-I could induce various immune responses in mice immunization experiments, including increase antibody production and cytokines IL-4 and IFN-γ level, and induce T-cell immunophenotyping. These results suggest that BPP-I is a potential immunomodulator of antitumor and immunity. The study could provide some novel insights on the probable candidate reagent for the antitumor and immune improvement.

分类号： Q5

  • 相关文献
作者其他论文 更多>>

微信小程序