A 90-day safety study of genetically modified rice expressing rhIGF-1 protein in C57BL/6J rats

文献类型： 外文期刊

第一作者： Tang, Maoxue

作者： Tang, Maoxue;Cheng, Wenke;Qian, Lili;Yang, Shulin;Cui, Wentao;Li, Kui;Tang, Maoxue;Cheng, Wenke;Qian, Lili;Yang, Shulin;Cui, Wentao;Li, Kui;Xie, Tingting;Yang, Daichang

作者机构：

关键词： adverse effects;biosafety;gene expression;genes;genetic engineering;genetic transformation;rice;transgenic plants;Oryza;Oryza sativa;plants;rats;Oryza;Poaceae;Cyperales;monocotyledons;angiosperms;Spermatophyta;plants;eukaryotes;Muridae;rodents;mammals;vertebrates;Chordata;animals;adverse reactions;genetic manipulation;genetically engineered plants;genetically modified plants;GMOs;paddy

期刊名称：TRANSGENIC RESEARCH （ 影响因子：2.788； 五年影响因子：2.377 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Genetically modified plants expressing disease resistance traits offer new treatment strategies for human diseases, but at the same time present a challenge in terms of food safety assessment. The present 90-day feeding study was designed to assess the safety of transgenic rice expressing the recombinant human insulin-like growth factor-1 (rhIGF-1) compared to its parental wild rice. Male and female C57BL/6J rats were given a nutritionally balanced purified diet with 20% transgenic rhIGF-1 rice or 20% parental rice for 90 days. This corresponds to a mean daily rhIGF-1 protein intake of approximately 217.6 mg/kg body weight based on the average feed consumption. In the animal study a range of biological, biochemical, clinical, microbiological and pathological parameters were examined and several significant differences were observed between groups, but none of the effects were considered to be adverse. In conclusion, no adverse or toxic effects on C57BL/6J rats were observed in the design used in this 90-day study. These results will provide valuable information for the safety assessment of genetically modified food crops.

分类号： R394

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