Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle

文献类型: 外文期刊

第一作者: Yuan, Zhengrong

作者: Yuan, Zhengrong;Li, Junya;Li, Jiao;Zhang, Lupei;Gao, Xue;Gao, Hui Jiang;Xu, Shangzhong;Yuan, Zhengrong

作者机构:

关键词: BRCA1 gene;Cattle;Mastitis;Single nucleotide polymorphisms;Somatic cell count;Somatic cell score

期刊名称:GENE ( 影响因子:3.688; 五年影响因子:3.329 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The main objective of this study was to investigate whether the bovine breast cancer 1 (BRCA1) gene was associated with mastitis resistance in Chinese commercial cattle. A total of 51 SNPs were screened from public data resources and DNA sequencing. Three SNPs (c.5682. G>C,c.26198. C>T and c.46126. G>T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and created restriction site PCR (CRS-PCR) methods and 21 combinations of these SNPs were observed. The single SNP and their genetic effects on somatic cell score (SCS) were evaluated and a significant association with SCS was found in c.46126. G>T. The mean SCS of individuals with genotype KK was significantly lower than those of genotypes KL and LL. The results of combined genotypes analysis of three SNPs showed that HHLLNN genotype with the highest SCS was easily for the mastitis susceptibility, whereas GGKKMM genotype with the lowest SCS was favorable for the mastitis resistance. The information provided in the present study will be very useful for improving mastitis resistance in dairy cattle by marker-assisted selection (MAS).

分类号: R394

  • 相关文献

[1]BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score. Yuan, Zhengrong,Chu, Guiyan,Dan, Yang,Liu, Zhihua,Li, Jiao,Zhang, Lupei,Gao, Xue,Gao, Huijiang,Li, Junya,Xu, Shangzhong.

[2]SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene. Yuan, Zhengrong,Li, Jiao,Li, Junya,Gao, Xue,Xu, Shangzhong,Yuan, Zhengrong,Yuan, Zhengrong.

[3]Haplotype analysis of TLR4 gene and its effects on milk somatic cell score in Chinese commercial cattle. Wang, Xing Ping,Zhuo Ma Luoreng,Guo, Dong Sheng,Li, Feng,Chen, Gang,Wang, Jin Ren,Gao, Shu Xin,Li, Jun Ya,Gao, Xue,Xu, Shang Zhong.

[4]Novel SNPs polymorphism of bovine CACNA2D1 gene and their association with somatic cell score. Yuan, Zheng-rong,Li, Jiao,Zhang, Lu-pei,Zhang, Li-min,Chen, Cui,Chen, Xiao-jie,Gao, Xue,Li, Jun-ya,Chen, Jin-bao,Gao, Hui-jian,Xu, Shang-zhong. 2011

[5]Identification mutation of the CACNA2D1 gene and its effect on somatic cell score in cattle. Deng, Gui-xin,Yuan, Zheng-rong,Gao, Xue,Li, Jun-ya,Chen, Jin-bao,Gao, Hui-jiang,Xu, Shang-zhong. 2011

[6]Molecular cloning of the HGD gene and association of SNPs with meat quality traits in Chinese red cattle. Cao, Yang,Zhang, Lichun,Jin, Haiguo,Li, Mei,Dudgeon, Crissy,Zhou, Guoli,Zhou, Guoli.

[7]Variants and Gene Expression of the TLR2 Gene and Susceptibility to Mastitis in Cattle. Huang, Jinming,Liu, Li,Wang, Hongmei,Zhang, Cuixia,Ju, Zhihua,Wang, Changfa,Zhong, Jifeng.

[8]Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of the BOLA-DQA2 Gene in Dairy Cattle. Hou, Qinlei,Huang, Jinming,Ju, Zhihua,Li, Qiuling,Li, Liming,Wang, Changfa,Sun, Tao,Wang, Lingling,Hou, Minghai,Zhong, Jifeng,Hang, Suqin.

[9]Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli. Zhang, Zijing,Guo, Fang,Luo, Guojing,Xu, Yinxue,Wang, Xiuge,Li, Rongling,Ju, Zhihua,Qi, Chao,Zhang, Yan,Li, Qiuling,Wang, Changfa,Zhong, Jifeng,Huang, Jinming.

[10]Three novel SNPs of the bovine Tf gene in Chinese native cattle and their associations with milk production traits. Ju, Z. H.,Li, Q. L.,Huang, J. M.,Hou, M. H.,Li, R. L.,Li, J. B.,Zhong, J. F.,Wang, C. F.. 2011

[11]Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins. Zhao, Z. L.,Zhang, J. B.,Zhao, Z. L.,Wang, C. F.,Li, Q. L.,Ju, Z. H.,Huang, J. M.,Li, J. B.,Zhong, J. F.. 2012

[12]Genetic parameters for somatic cell score and production traits in the first three lactations of Chinese Holstein cows. Zhao Fu-ping,Guo Gang,Du Li-xin,Guo Gang,Guo Gang,Wang Ya-chun,Guo Xiang-yu,Zhang Yuan. 2015

[13]Two single nucleotide polymorphisms sites in alpha 1-AT gene and their association with somatic cell score in Chinese Holstein cows. Guo, Xiao-Fei,Hu, Wen-Ping,Wang, Xiang-Yu,Di, Ran,Liu, Qiu-Yue,Chu, Ming-Xing,Lang, Xian-Zheng,Liu, Xiao-Lin,Li, Qiu-Ling,An, Yong-Fu,Guo, Xiao-Fei. 2017

[14]Polymorphism of exon 2 of BoLA-DRB3 gene and its relationship with somatic cell score in Beijing Holstein cows. Chu, M. X.,Ye, S. C.,Wang, J. X.,Feng, T.,Huang, D. W.,Cao, G. L.,Di, R.,Fang, L.,Qiao, L.,Chen, G. H..

[15]Polymorphism analysis of the intron one of insulin-like growth factor 2 receptor gene (IGF2R) in FFRC strain common carp (Cyprinus carpio L.) and its relationship with growth performance. Dong, Z. J.,Xie, Z.,Dong, Z. J.,Su, S. Y.,Zhu, W. B.,Zhang, C. F.,Yuan, X. H.,Dong, Z. J.,Ding, M.,Chen, W. X.,Yuan, X. H.. 2015

[16]Association analysis of aquaporin 7 (AQP7) gene variants with semen quality and fertility in bulls. Ma, Teng-He,Liu, Ji-Feng,Jiang, Hao,Dai, Li-Sheng,Zhang, Jia-Bao,Ma, Teng-He,Liu, Ji-Feng,Jiang, Hao,Dai, Li-Sheng,Zhao, Zhi-Hui,Zhao, Rui-Feng,Zhao, Yu-Min.

[17]Associations between polymorphisms of the STAT1 gene and milk production traits in water buffaloes. Deng, T. X.,Pang, C. Y.,Lu, X. R.,Zhu, P.,Duan, A. Q.,Liang, X. W..

[18]Genome-wide polymorphisms between the parents of an elite hybrid rice and the development of a novel set of PCR-based InDel markers. Wang, K.,Zhuang, J. Y.,Huang, D. R.,Ying, J. Z.,Fan, Y. Y.. 2015

[19]Identification of positive selection signatures in pigs by comparing linkage disequilibrium variances. Li, X.,Fan, B.,Liu, B.,Li, X.,Liu, B.,Li, X.,Wang, Z.,Yang, S.,Dong, K.,Tang, Z.,Li, K..

[20]Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor (ATBF1) Gene. Zhang, Xiaoyan,Wu, Xianfeng,Pan, Chuanying,Lei, Chuzhao,Chen, Hong,Lan, Xianyong,Jia, Wenchao,Li, Xiangcheng.

作者其他论文 更多>>
  • Transcriptomic and metabolomic analysis of recalcitrant phosphorus solubilization mechanisms in Trametes gibbosa

    作者:Chen, Yulan;Farooq, Akasha;Wei, Xieluyao;Qin, Leitao;Wang, Yong;Zhang, Lingzi;Xiang, Quanju;Zhao, Ke;Yu, Xiumei;Chen, Qiang;Penttinen, Petri;Gu, Yunfu;Gao, Xue;Nyima, Tashi

    关键词:phosphate solubilizing fungi; transcriptomic analysis; metabolomic analaysis; phosphorus solubilization mechanism; bio-phosphate fertilizer

  • Genome-Wide Scans for Selection Signatures in Ningxia Angus Cattle Reveal Genetic Variants Associated with Economic and Adaptive Traits

    作者:Yin, Haiqi;Wang, Yaxuan;Peng, Ruiqi;Wang, Yahui;Zhao, Tong;Zheng, Caihong;Xu, Lingyang;Gao, Xue;Gao, Huijiang;Li, Junya;Wang, Zezhao;Zhang, Lupei;Feng, Yuan;Wang, Yu;Jiang, Qiufei;Zhao, Jie;Zhang, Juan;Chen, Yafei

    关键词:Angus cattle; whole-genome resequencing; selection signatures; iHS; immune-related gene; economic trait

  • Multiple strategies association revealed functional candidate FASN gene for fatty acid composition in cattle

    作者:Zhu, Bo;Wang, Tianzhen;Niu, Qunhao;Wang, Zezhao;Xu, Lei;Chen, Yan;Zhang, Lupei;Gao, Xue;Gao, Huijiang;Xu, Lingyang;Li, Junya;Zhu, Bo;Hay, El Hamidi;Xu, Lei;Cao, Yang;Zhao, Yumin;Cao, Yang;Zhao, Yumin

    关键词:

  • Mitigating Cell Cycle Effects in Multi-Omics Data: Solutions and Analytical Frameworks

    作者:Nie, Rui;Ren, Likun;Teng, Yue;Cai, Jun;Nie, Rui;Ren, Likun;Teng, Yue;Cai, Jun;Nie, Rui;Ren, Likun;Teng, Yue;Cai, Jun;Zheng, Caihong;Li, Junya;Sun, Yaoyu;Wang, Lifei

    关键词:cell cycle compositions; pseudo-omics features; S phase ratios

  • Deciphering the Population Characteristics of Leiqiong Cattle Using Whole-Genome Sequencing Data

    作者:Guo, Yingwei;Ge, Fei;Lyu, Chenxiao;Liu, Yuxin;Li, Junya;Chen, Yan;Zhao, Zhihui;Yu, Haibin;Lyu, Chenxiao

    关键词:population genetics; genomic characteristics; Leiqiong cattle; selective sweep

  • EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research

    作者:Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang

    关键词:metagenome; microbiome; microbiota; pipeline; visualization

  • Biochemical and molecular responses of Babylonia areolata to cadmium stress

    作者:Luan, Ke-Er;Zheng, Pei-Hua;Xu, Tong;Li, Jiao;Lu, Yao-Peng;Zhang, Ze-Long;Hou, Wei-Yan;Li, Jun-Tao;Xian, Jian-An;Xu, Tong;Li, Jiao;Cheng, Hai-Tao;Xian, Jian-An

    关键词:Babylonia areolate; Cadmium; Oxidative stress; Heavy metal; Transcriptome