Characterization of an attenuated TE3L-deficient vaccinia virus Tian Tan strain

文献类型: 外文期刊

第一作者: Wang, Yuhang

作者: Wang, Yuhang;Kan, Shifu;Du, Shouwen;Qi, Yanxin;Wang, Jinhui;Liu, Liming;Ji, Huifan;He, Dongyun;Wu, Na;Li, Chang;Li, Xiao;Jin, Ningyi;Wang, Jinhui;Liu, Liming;Ji, Huifan;He, Dongyun;Chi, Baorong;Li, Xiao

作者机构:

关键词: Attenuated vaccinia virus vector;Immunogenicity;TE3L;Tian Tan strain;Virulence

期刊名称:ANTIVIRAL RESEARCH ( 影响因子:5.97; 五年影响因子:5.801 )

ISSN:

年卷期:

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收录情况: SCI

摘要: An attenuated vaccinia virus (VACV), TE3L-VTT, was evaluated for virulence and safety to determine its potential use as a vaccine or as a recombinant virus vector to express foreign genes. The virulence of TE3L-VTT was compared with that of the wild-type VTT both in vivo and in vitro. The humoral and cellular immune responses were detected in a mouse model to test the vaccine efficacy of the TE3L mutant. The results suggested that deletion of the TE3L gene decreased the virulence and neurovirulence significantly in mice and rabbit models, yet retained the immunogenicity. Thus, the deletion of TE3L improved the safety of the VTT vector; this approach may yield a valuable resource for studies of recombinant VACV-vectored vaccines.

分类号: R37

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