Assessment of toxic effects of triclosan on the swordtail fish (Xiphophorus helleri) by a multi-biomarker approach

文献类型： 外文期刊

第一作者： Liang, Ximei

作者： Liang, Ximei;Nie, Xiangping;Ying, Guangguo;An, Taicheng;Li, Kaibing

作者机构：

关键词： triclosan;swordtail fish (xiphophorus helleri);toxic effects;gene expression;enzymatic activities

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

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收录情况： SCI

摘要： The toxic effects of triclosan (TCS) on the swordtail fish (Xiphophorus helleri) were assessed based on various biomarkers including enzymatic activities of ethoxyresorufin O-deethylase (EROD), erythromycin N-demethylase (ERND) and glutathione-s-transferase (GST) and mRNA expression levels of CYP1A, CYP3A, glutathione S-transferase (GST) and P-glycoprotein (P-gp). The acute toxicity test showed the LC_(50) value of 1.47 mg L~(-1) for TCS. The mRNA expressions of CYP1A, CYP3A, GST and P-gp showed dose-effect relationships in female swordtail fish when exposed to TCS, These mRNA expression levels were found more sensitive to TCS exposure than the enzymatic activities of EROD, ERND and GST do. In addition, the male fish displayed higher gene expression levels and more dramatic changes in enzyme activities than the females did. Our data further demonstrated that TCS was a typical inducer to Phase 1 and Phase Ⅱ metabolism enzymes and genes, suggesting it is a potential ecotoxicological risk to aquatic ecosystems.

分类号： X5

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