Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release

文献类型: 外文期刊

第一作者: Zhu, Kunkun

作者: Zhu, Kunkun;Ye, Ting;Liu, Jinjin;Xu, Shasha;Lei, Jieqiong;Deng, Hongbing;Li, Bin;Zhu, Kunkun;Ye, Ting;Liu, Jinjin;Xu, Shasha;Lei, Jieqiong;Deng, Hongbing;Li, Bin;Zhu, Kunkun;Peng, Zheng

作者机构:

关键词: CMC;Drug delivery;Electrostatic attraction;Lysozyme;Nanogels

期刊名称:INTERNATIONAL JOURNAL OF PHARMACEUTICS ( 影响因子:5.875; 五年影响因子:5.423 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Lysozyme (Ly) and sodium carboxymethyl cellulose (CMC) were used to fabricate nanogels by a convenient method without using any chemical treatment except simple heating to achieve the denaturation temperature of Ly. The prepared nanogels were characterized by dynamic laser scattering (DLS), rheological analysis, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The nanogels are of spherical shape with average hydrodynamic diameter of 241 nm and the swelling ratio of nanogels is about 5. Then 5-fluorouracil was used as a model drug to investigate the entrapment efficiency and release ability in nanogels. It turned out to be that the release in simulated gastric fluid (SGF) was more slowly compared with that in simulated intestinal fluid (SIF), which could protect the 5-Fu in stomach and ensure it released in intestines. ? 2012 Elsevier B.V. All rights reserved.

分类号: R9

  • 相关文献

[1]Purification and properties of lysozyme from a marine strain. Zhang, Xiu,Ren, Xian,Zhang, Xiu,Wang, Yue-Jun,Sun, Mi,Zou, Yan-Li,Wang, Qing-Yin,Wang, Wei. 2008

[2]Dilational rheology of different globular protein with imidazolium-based ionic liquid surfactant adsorption layer at the decane/water interface. Zhou, Zhao-Lu,Zheng, Li,Huang, Qi-Liang,Du, Feng-Pei. 2017

[3]Chinese herbs (Astragalus membranaceus and Lonicera japonica) and boron enhance the non-specific immune response of Nile tilapia (Oreochromis niloticus) and resistance against Aeromonas hydrophila. Ardo, Laszlo,Varadi, Laszlo,Jeney, Zsigmond,Jeney, Galina,Yin, Guojun,Xu, Pao,Szigeti, Gabor.

[4]Preparation and evaluation of lysozyme-loaded nanoparticles coated with poly-gamma-glutamic acid and chitosan. Liu, Yong,Xu, Yaoxing,Tang, Jiangwu,Liu, Wei,Sun, Dongchang,Jiang, Hua,Xu, Shaochun,Sun, Yan,Fu, Sida,Feng, Hai. 2013

[5]Colorimetric and fluorometric dual-readout sensor for lysozyme. Zheng, Hanye,Qiu, Suyan,Xu, Kefeng,Lin, Zhenyu,Guo, Longhua,Qiu, Bin,Chen, Guonan,Qiu, Suyan,Luo, Linguang,Song, Yibiao.

[6]Effect of high dietary carbohydrate on growth, serum physiological response, and hepatic heat shock cognate protein 70 expression of the top-mouth culter Erythroculter ilishaeformis Bleeker. Liu, Bo,Xie, Jun,Ge, Xian-ping,Wang, Guangyu,Liu, Bo,Xie, Jun,Ge, Xian-ping,Miao, Ling-hong.

[7]Immune responses and expression of immune-related genes in swimming crab Portunus trituberculatus exposed to elevated ambient ammonia-N stress. Yue, Feng,Pan, Luqing,Xie, Peng,Zheng, Debin,Li, Jian.

[8]Expression of Apostichopus japonicus lysozyme in the methylotrophic yeast Pichia pastoris. Wang, Tingting,Xu, Yongping,Liu, Wenjia,Jin, Liji,Xu, Yongping,Jin, Liji,Sun, Yongxin,Wang, Tingting,Xu, Yongping,Liu, Wenjia,Sun, Yongxin,Jin, Liji.

[9]Selective synthesis of Fe3O4AuxAgy nanomaterials and their potential applications in catalysis and nanomedicine. Fodjo, Essy Kouadio,Serge, Brou Yapi,Trokourey, Albert,Gabriel, Koffi Mouroufie,Li, Dan,Kong, Cong. 2017

[10]Foot-and-mouth disease virus-like particles as integrin-based drug delivery system achieve targeting anti-tumor efficacy. Yan, Dan,Teng, Zhidong,Sun, Shiqi,Dong, Hu,Gao, Yuan,Wei, Yanquan,Liu, Xiangtao,Yin, Hong,Guo, Huichen,Yan, Dan,Teng, Zhidong,Sun, Shiqi,Dong, Hu,Gao, Yuan,Wei, Yanquan,Liu, Xiangtao,Yin, Hong,Guo, Huichen,Jiang, Shan,Qin, Wenwu. 2017

[11]Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon. Li, Puwang,Yang, Ziming,Peng, Zheng,Li, Sidong,Kong, Lingxue,Wang, Qinghuang,Wang, Yichao,Kong, Lingxue,Wang, Qinghuang. 2015

[12]Cutting Edge Protein and Carbohydrate-Based Materials for Anticancer Drug Delivery. Ahmad, Rasheed,Deng, Yan,Hussain, Mubashir,He, Nongyue,Ahmad, Rasheed,Sun, Yueming,Shah, Muhammad Ali Abdullah,Singh, Ravina,Elingarami, Sauli,Deng, Yan,He, Nongyue. 2018

[13]The application of virus-like particles as vaccines and biological vehicles. Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi,Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi.

[14]Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer. Wang, Yichao,Wang, Yichao,Li, Puwang,Thao Truong-Dinh Tran,Zhang, Juan,Kong, Lingxue,Li, Puwang,Thao Truong-Dinh Tran. 2016

[15]Nanostructured calcium phosphate carriers for deliver of poor water-soluble drug silybin. Chen, Lei,Zhu, Hualing,Yang, Song,Zhou, Beibei,You, Fenghui,Yan, Xiaoming.

作者其他论文 更多>>