Interferon induction and suppression in swine testicle cells by porcine parvovirus and its proteins

文献类型： 外文期刊

第一作者： Lin, Wencheng

作者： Lin, Wencheng;Qiu, Zheng;Liu, Qinfang;Cui, Shangjin

作者机构：

关键词： Luciferase;Porcine parvovirus quantitative real time PCR;Type I interferon

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Porcine parvovirus (PPV) is a major causative agent of reproductive failure in swine, which currently affects the swine industry worldwide. Although PPV was identified several years ago, little is known about how it overcomes host innate immunity. In this study, we used quantitative real-time PCR and a luciferase reporter assay to determine whether PPV infection induces type I interferon (IFN-alpha and IFN-beta) and whether PPV infection blocks dsRNA-induced IFN-beta promoter activation in cell cultures. The results indicate that PPV does not induce type I interferon and that the NS2 protein of PPV could blocks dsRNA-induced IFN-beta promoter activation

分类号： S8

  • 相关文献

[1]Microplate Luminometry for Toxicity Bioassay of Chemicals on Luciferase. Ge Hui-lin,Luo Jin-hui,Lu Dai-zhu,Su Bing-xia,Ge Hui-lin,Liu Shu-shen,Chen Fu. 2013

[2]Construction and application of a built-in dual luciferase reporter for microRNA functional analysis. Bi, Yanzhen,Zheng, Xinmin,Shao, Changwei,Jiang, Li,Ouyang, Huiwu,Pan, Wen. 2011

[3]Establishment of real-time TaqMan-fluorescence quantitative RT-PCR assay for detection and quantitation of ten kinds of porcine inflammation markers mRNA. Lin, Wencheng,Qiu, Zheng,Liu, Qinfang,Cui, Shangjin,Wang, Zhongtian.

[4]The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide. Liu, Xiao-Dan,Ruan, Jin-Xue,Xia, Ji-Han,Yang, Shu-Lin,Fan, Jun-Hua,Li, Kui.

[5]Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53. Zhu, Zixiang,Yang, Yifan,Wei, Jianchao,Shao, Donghua,Shi, Zixue,Li, Beibei,Liu, Ke,Qiu, Yafeng,Ma, Zhiyong,Zhu, Zixiang,Zheng, Haixue.

[6]Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Li, Liwei,Zhou, Yanjun,Gao, Fei,Jiang, Yifeng,Yu, Lingxue,Zheng, Hao,Tong, Wu,Yang, Shen,Zheng, Haihong,Shan, Tongling,Liu, Fei,Xia, Tianqi,Tong, Guangzhi,Wei, Zuzhang,Zhou, Yanjun,Gao, Fei,Tong, Guangzhi.

[7]Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway. Li, Lian-Feng,Yu, Jiahui,Zhang, Yuexiu,Yang, Qian,Li, Yongfeng,Zhang, Lingkai,Wang, Jinghan,Li, Su,Luo, Yuzi,Sun, Yuan,Qiu, Hua-Ji.

[8]Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase. Ge, Hui-Lin,Su, Bing-Xia,Ge, Hui-Lin,Liu, Shu-Shen,Zhu, Xiang-Wei.

作者其他论文 更多>>

微信小程序