Parametric proportional hazards model for mapping genomic imprinting of survival traits

文献类型： 外文期刊

第一作者： Gao, Huijiang

作者： Gao, Huijiang;Liu, Yongxin;Zhang, Tingting;Yang, Runqing;Yang, Runqing;Prows, Daniel R.;Prows, Daniel R.

作者机构：

关键词： Cox proportional hazards model;Imprinted quantitative trait loci;Mapping;Optimisation;Survival distribution;Survival trait

期刊名称：JOURNAL OF APPLIED GENETICS （ 影响因子：3.24； 五年影响因子：2.756 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： A number of imprinted genes have been observed in plants, animals and humans. They not only control growth and developmental traits, but may also be responsible for survival traits. Based on the Cox proportional hazards (PH) model, we constructed a general parametric model for dissecting genomic imprinting, in which a baseline hazard function is selectable for fitting the effects of imprinted quantitative trait loci (iQTL) genotypes on the survival curve. The expectation-maximisation (EM) algorithm is derived for solving the maximum likelihood estimates of iQTL parameters. The imprinting patterns of the detected iQTL are statistically tested under a series of null hypotheses. The Bayesian information criterion (BIC) model selection criterion is employed to choose an optimal baseline hazard function with maximum likelihood and parsimonious parameterisation. We applied the proposed approach to analyse the published data in an F-2 population of mice and concluded that, among five commonly used survival distributions, the log-logistic distribution is the optimal baseline hazard function for the survival time of hyperoxic acute lung injury (HALI). Under this optimal model, five QTL were detected, among which four are imprinted in different imprinting patterns.

分类号： Q1

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