Linkage Disequilibrium Estimation of Chinese Beef Simmental Cattle Using High-density SNP Panels

文献类型: 外文期刊

第一作者: Zhu, M.

作者: Zhu, M.;Zhu, B.;Wang, Y. H.;Wu, Y.;Xu, L.;Guo, L. P.;Yuan, Z. R.;Zhang, L. P.;Gao, X.;Gao, H. J.;Xu, S. Z.;Li, J. Y.;Zhu, B.

作者机构:

关键词: Chinese Beef Simmental Cattle;Bovine Genome;Linkage Disequilibrium;Single Nucleotide Polymorphis

期刊名称:ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES ( 影响因子:2.509; 五年影响因子:2.604 )

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收录情况: SCI

摘要: Linkage disequilibrium (LD) plays an important role in genomic selection and mapping quantitative trait loci (QTL). In this study, the pattern of LD and effective population size (Ne) were investigated in Chinese beef Simmental cattle. A total of 640 bulls were genotyped with IlluminaBovinSNP50BeadChip and IlluminaBovinHDBeadChip. We estimated LD for each autosomal chromosome at the distance between two random SNPs of <0 to 25 kb, 25 to 50 kb, 50 to 100 kb, 100 to 500 kb, 0.5 to 1 Mb, 1 to 5 Mb and 5 to 10 Mb. The mean values of r(2) were 0.30, 0.16 and 0.08, when the separation between SNPs ranged from 0 to 25 kb to 50 to 100 kb and then to 0.5 to 1 Mb, respectively. The LD estimates decreased as the distance increased in SNP pairs, and increased with the increase of minor allelic frequency (MAF) and with the decrease of sample sizes. Estimates of effective population size for Chinese beef Simmental cattle decreased in the past generations and N-e was 73 at five generations ago.

分类号: Q95

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