Self-Assembled Phytosterol-Fructose-Chitosan Nanoparticles as a Carrier of Anticancer Drug

文献类型： 外文期刊

第一作者： Qiu, Yeyan

作者： Qiu, Yeyan;Zhu, Jun;Wang, Jianting;Gong, Renmin;Qiu, Yeyan;Zheng, Mingming;Huang, Fenghong

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关键词： Water-Soluble Chitosan;Phytosterol;Self-Assembled Nanoparticle;Anticancer Drug;Targeted Delivery

期刊名称：JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY （ 影响因子：1.134； 五年影响因子：0.999 ）

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收录情况： SCI

摘要： Self-assembled nanoparticles were synthesized from water-soluble fructose-chitosan, substituted by succinyl linkages with phytosterols as hydrophobic moieties for self-assembly. The physicochemical properties of the prepared self-assembled nanoparticles were characterized by Fourier transform infrared spectroscopy, fluorescence spectroscopy, and transmission electron microscopy. Doxorubicin (DOX), as a model anticancer drug, was physically entrapped inside prepared self-assembled nanoparticles by the dialysis method. With increasing initial levels of the drug, the drug loading content increased, but the encapsulation efficiency decreased. The release profiles in vitro demonstrated that the DOX showed slow sustained released over 48 h, and the release rate in phosphate buffered saline (PBS) solution (pH 7.4) was much slower than in PBS solution (pH 5.5 and pH 6.5), indicating the prepared self-assembled nanoparticles had the potential to be used as a carrier for targeted delivery of hydrophobic anticancer drugs with declined cytotoxicity to normal tissues.

分类号： TB383

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