A novel chemoenzymatic synthesis of propyl caffeate using lipase-catalyzed transesterification in ionic liquid

文献类型： 外文期刊

第一作者： Pang, Na

作者： Pang, Na;Gu, Shuang-Shuang;Wang, Jun;Cui, Hong-Sheng;Wang, Fang-Qin;Liu, Xi;Zhao, Xing-Yu;Wu, Fu-An;Wu, Fu-An

作者机构：

关键词： Biocatalysis;Ionic liquid;Lipase;Propyl caffeate;Transesterification

期刊名称：BIORESOURCE TECHNOLOGY （ 影响因子：9.642； 五年影响因子：9.237 ）

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收录情况： SCI

摘要： Propyl caffeate has the highest antioxidant capacity in the caffeate alkyl esters family, but industrial production of propyl caffeate is hindered by low yields using either the chemical or enzymatic catalysis method. To set up a high-yield process for obtaining propyl caffeate, a novel chemoenzymatic synthesis method using lipase-catalyzed transesterification of an intermediate methyl caffeate or ethyl caffeate and 1-propanol in ionic liquid was established. The maximum propyl caffeate yield of 98.5% was obtained using lipase-catalyzed transesterification under the following optimal conditions: Novozym 435 as a biocatalyst, [Bmim][CF_3SO_3] as a medium, a molar ratio of methyl caffeate to 1-propanol of 1:5, a mass ratio of methyl caffeate to lipase of 1:20, and a reaction temperature of 60°C. The two-step conversion of caffeic acid to propyl caffeate via methyl caffeate is an efficient way to prepare propyl caffeate with an overall yield of 82.7%.

分类号： Q

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