H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet

文献类型： 外文期刊

第一作者： Zhang, Qianyi

作者： Zhang, Qianyi;Shi, Jianzhong;Deng, Guohua;Guo, Jing;Zeng, Xianying;He, Xijun;Kong, Huihui;Gu, Chunyang;Li, Xuyong;Liu, Jinxiong;Wang, Guojun;Chen, Yan;Liu, Liling;Liang, Libin;Li, Yuanyuan;Fan, Jun;Wang, Jinliang;Li, Wenhui;Guan, Lizheng;Li, Qimeng;Yang, Huanliang;Chen, Pucheng;Jiang, Li;Guan, Yuntao;Xin, Xiaoguang;Jiang, Yongping;Tian, Guobin;Wang, Xiurong;Qiao, Chuanling;Li, Chengjun;Bu, Zhigao;Chen, Hualan;Zhang, Qianyi;Gu, Chunyang;Wang, Guojun;Li, Qimeng;Chen, Hualan

作者机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150001, Peoples R China;Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin

期刊名称：SCIENCE （ 2020影响因子：47.728； 五年影响因子：51.433 ）

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收录情况： SCI

摘要： A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.

分类号： N

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