ADVANCED HYPHENATED CHROMATOGRAPHIC-MASS SPECTROMETRY IN MYCOTOXIN DETERMINATION: CURRENT STATUS AND PROSPECTS

文献类型： 外文期刊

第一作者： Li, Peiwu

作者： Li, Peiwu;Zhang, Zhaowei;Hu, Xiaofeng;Zhang, Qi;Li, Peiwu;Zhang, Zhaowei;Li, Peiwu;Zhang, Zhaowei;Hu, Xiaofeng;Li, Peiwu;Hu, Xiaofeng;Zhang, Qi;Li, Peiwu;Zhang, Qi

作者机构：

关键词： mycotoxin;hyphenated chromatographic-mass spectrometry;liquid chromatography;gas chromatography

期刊名称：MASS SPECTROMETRY REVIEWS （ 影响因子：10.946； 五年影响因子：9.617 ）

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收录情况： SCI

摘要： Mass spectrometric techniques are essential for advanced research in food safety and environmental monitoring. These fields are important for securing the health of humans and animals, and for ensuring environmental security. Mycotoxins, toxic secondary metabolites of filamentous fungi, are major contaminants of agricultural products, food and feed, biological samples, and the environment as a whole. Mycotoxins can cause cancers, nephritic and hepatic diseases, various hemorrhagic syndromes, and immune and neurological disorders. Mycotoxin-contaminated food and feed can provoke trade conflicts, resulting in massive economic losses. Risk assessment of mycotoxin contamination for humans and animals generally depends on clear identification and reliable quantitation in diversified matrices. Pioneering work on mycotoxin quantitation using mass spectrometry (MS) was performed in the early 1970s. Now, unambiguous confirmation and quantitation of mycotoxins can be readily achieved with a variety hyphenated techniques that combine chromatographic separation with MS, including liquid chromatography (LC) or gas chromatography (GC). With the advent of atmospheric pressure ionization, LC-MS has become a routine technique. Recently, the cooccurrence of multiple mycotoxins in the same sample has drawn an increasing amount of attention. Thus, modern analyses must be able to detect and quantitate multiple mycotoxins in a single run. Improvements in tandem MS techniques have been made to achieve'this purpose. This review describes the advanced research that has been done regarding mycotoxin determination using hyphenated chromatographic-MS techniques, but is not a full-circle survey of all the literature published on this topic. The present work provides an overview of the various hyphenated chromatographic-MS-based strategies that have been applied to mycotoxin analysis, with a focus on recent developments. The use of chromatographic-MS to measure levels of mycotoxins, including aflatoxins, ochratoxins, patulin, trichothecenes, zear-alenone, and funionisms, is discussed in detail. Both free and masked mycotoxins are included in this review due to different methods of sample preparation. Techniques are described in terms of sample preparation, internal standards, LC/ultra performance LC (UPLC) optimization, and applications and survey. Several future hyphenated MS techniques are discussed as well, including multidimensional chromatography-MS, capillary electrophoresis-MS, and surface plasmon resonance array-MS. ? 2013 Wiley Periodicals, Inc. Mass Spec Rev 32:420-452,2013

分类号： O657.63

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